MAB-anti-DNA related to nephritis

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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436501, 436528, 436530, 436531, 436538, 436548, 436811, 935110, G01N 3300, G01N 3353

Patent

active

048123978

ABSTRACT:
Novel compositions and methods are provided for detecting lupus nephritis in patients suffering from SLE. Competitive or non-competitive assays may be employed, where monoconal antibodies may be used to compete with antiserum for a nucleic acid ligand or may be used for the detection of antiidiotype antibodies as diagnostic of the presence or absence of lupus nephritis.

REFERENCES:
patent: 3897212 (1975-07-01), Leon et al.
patent: 4623627 (1986-11-01), Huang et al.
patent: 4690905 (1987-09-01), Diamond
Hahn, B. et al., "Suppression of Murine Lupus Nephritis . . . ", J. Immunology 132(1), 187-190 (Jan., 1984).

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