M6P/IGF-II receptor tumor suppressor gene

Details M6P/IGF-II receptor tumor suppressor gene M6P/IGF-II receptor tumor suppressor gene

1996-11-15

1999-02-23

Myers, Carla J.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

436 64, 436 94, 536 235, 935 77, 935 78, C12Q 168, C07H 2104

Patent

active

058742220

ABSTRACT:
The present invention relates, in general, to a tumor suppressor and, in particular, to the mannose 6-phosphate/insulin-like growth factor-II (M6P/IGF-II) receptor and to diagnostic and therapeutic approaches based on same.

REFERENCES:
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Hankins et al, "The Role of Growth Factors in Liver Regeneration and Tumor Promotion", FASEB Journal, p. A1029, Abstract No. 538 (1992).
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De Souza et al. FASEB Journal. 9(3): A124, Abstract #725, Mar. 1995.
De Souza et al, "M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity", Nature Genetics 11:447-449 (1995).
Laurenzi et al, "The Expression of the Type II Insulin-Like Growth Factor Receptor (M6"/IGF-II Receptor) in a Human Glioblastoma-Derived Cell Line", Neuroscience Research Communications 16(1):37-43 (1995).
Ellis et al, "Affinity for the Insulin-Like Growth Factor-II (IGF-II) Receptor Inhibits Autocrine IGF-II Activity in MCF-7 Breast Cancer Cells", Molecular Endocrinology 10(3):286-297 (1996).
Hankins et al, "M6P/IGF2 receptor: a candidate breast tumor suppressor gene", Oncogene 12(9):2003-2009 (1996).
De Souza et al, "Frequent loss of heterozygosity on 6q at the mannose 6-phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors", Oncogene 10(9):1725-1729 (1995).
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