Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1978-01-13
1980-05-20
Tovar, Jose
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
544357, C07D29508, C07D29510, A61K 31495
Patent
active
042039860
ABSTRACT:
Compounds of the formula I ##STR1## wherein R.sub.1 represents a hydrogen or fluorine atom, and R.sub.2 represents an alkyl group containing 2 to 6 carbon atoms, or a cycloalkyl or cycloalkyl-alkyl group containing 5 to 8 carbon atoms, each of these groups being substituted by one or two hydroxy groups or an oxo group and, if desired, also by a 4-(m-trifluoromethylphenyl)-piperazino or 4-(3-trifluoromethyl-4-fluoro-phenyl)-piperazino group with the proviso that, when R.sub.1 represents a hydrogen atom, R.sub.2 does not represent a monohydroxyalkyl group, and their pharmaceutically acceptable acid addition salts are novel and have therapeutic use, notably in the region of the central nervous system and in the cardiovascular region.
REFERENCES:
patent: 3170926 (1965-02-01), Ash et al.
patent: 3253989 (1966-05-01), Moser et al.
patent: 3637705 (1972-01-01), Horrom et al.
patent: 3929792 (1975-12-01), Bouchara
patent: 3953449 (1976-04-01), Giudicelli et al.
Joullie Maurice
Lakah Lucien
Maillard Gabriel
Pascal Yves R. A.
Warolin Christian J. M.
Hueschen Gordon W.
Metabio-Joullie
Tovar Jose
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