M-protein peptides of influenza virus as antiviral agents

Details M-protein peptides of influenza virus as antiviral agents M-protein peptides of influenza virus as antiviral agents

1994-11-07

1997-04-01

Kim, Kay K. A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

424450, 530326, 530335, 530345, 530400, 530404, 530405, 530408, 530409, 514 13, 514 14, A61K 39385, A61K 3810, A61K 9127, C07K 1702

Patent

active

056163274

ABSTRACT:
Peptides substantially corresponding to the 148-162 region of type A influenza M protein and additionally containing at least one amino acid in the 163-166 region are disclosed to have high activity as influenza transcription inhibitors and thus as antiviral agents against influenza virus and other RNA viruses. The modification of these peptides by incorporation into liposomes or by addition of long-chain alkylamino acids is also shown as in the use of all such materials in antiviral drug formulations.

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