M-4 and iso M-4 derivatives, their preparation and compositions

Details M-4 and iso M-4 derivatives, their preparation and compositions M-4 and iso M-4 derivatives, their preparation and compositions

1984-03-19

1989-09-12

Lone, Werren B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

536 552, 544109, 548344, 548543, 556131, 556147, 556183, 560 38, 560119, 560155, 560156, 560256, A61K 31215, A61K 3122, C07C 6933, C07C 69675

Patent

active

048660930

ABSTRACT:
The dihydro-M-4 and dihydro-IsoM-4 hydroxy carboxylic acids of the formula (II): ##STR1## wherein one of R.sup.1 represents a hydrogen atom and the other represents a hydroxy group and wherein the structure shown as ##STR2## represents a structure of formula ##STR3## and the salts and esters of said acids. The invention also provides pharmaceutical compositions containing said acids, salts and/or esters which are useful for inhibiting cholesterol biosynthesis in the liver.

REFERENCES:
patent: 4342767 (1982-08-01), Albers-Schonberg
patent: 4346227 (1982-08-01), Terahara et al.
patent: 4420491 (1983-12-01), Albers-Schonberg
patent: 4438277 (1984-03-01), Terahara et al.
patent: 4444784 (1984-04-01), Hoffman et al.

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