Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Patent
1998-06-19
1999-10-12
Saunders, David
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
C07K 14735
Patent
active
059657120
ABSTRACT:
CD23 is a low affinity receptor for IgE. The extracellular part of this molecule has been linked to a modified leucine zipper. This results in a trimeric configuration, since the stalk region of the CD23 molecule is itself a weak leucine zipper. This chimeric protein, designated LZ-CD23, interacts with IgE in a much stronger fashion than either simply the extracellular domain alone or the intact membrane CD23. This is the result of an increased avidity due to the stable trimeric configuration. The chimera has approximately at 10,000 fold increased ability to block IgE binding to mast cell/basophils, compared to native soluble CD23. At approximately equal concentrations to added IgE, 80% inhibition of IgE binding to Fc.di-elect cons.RI on mast cells was obtained. Thus, the LZ-CD23 chimera provides a new means for blocking and binding which provides benefits in the treatment of IgE-mediated asthma and allergic diseases.
REFERENCES:
patent: 5554523 (1996-09-01), Reddy
Beavil, A.J., Alpha-helical coiled-coil stalks in the low-affinity receptor for IgE (FcepsilonRII/CD23) and related C-type lectins. Proc. Natl. Acad. Sci. USA. 89:753-757, Jan. l992.
Klein, N.J. II-4 regulates the morphology, cytoskeleton, and proliferation of human umbilical vein endothelial cells: relationship between vimentin and CD23. Internatl. Immunol. 5(3):293-301, 1993.
Sakuma, H., et al., Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage kinase from human brain. Jour. Biol. Chem. 272(45):28622-28629, Nov. 1997.
Conrad Daniel H.
Kelly Ann E.
Saunders David
Tung Mary Beth
Virginia Commonwealth University
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