Lyxofuranosyl analogues of adenosine

Details Lyxofuranosyl analogues of adenosine Lyxofuranosyl analogues of adenosine

1994-02-03

1996-04-09

Robinson, Douglas W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 272, 536 274, 536 2762, 536 2713, 544264, 544254, 544262, 544280, 544265, 544266, 544267, 544271, 544272, 544273, 544277, C07G 300, C07H 1916

Patent

active

055063470

ABSTRACT:
Novel lyxose derivatives which selectively inhibit adenosine kinase and methods of preparing these compounds are provided. These compounds are useful in treating certain conditions in vivo which may be ameliorated by increased local concentrations of adenosine.

REFERENCES:
Gupta et al., "Relationship Between Structure and Antiviral Activity of 5-Methoxymethyl-2'-Deoxyuridine and 5-Methoxymethyl-1-(2'deoxy-.alpha.-D-lyxofuranosyl)uracil," Antiviral Research, 7, 69-77 (1987).
Ealick et al., "Application of Crystallographic and Modeling Methods in the Design of Purine Nucleoside Phosphorylase Inhibitors," Proc. Nat. Acad. Sci. USA, 88, 11540-11544 (1991).
Bennett et al., "Structural Requirments for Activity of Nucleosides as Substrates for Adenosine Kinase. Orientation of Substituents on the Pentofuranosyl Ring," Mol. Pharmacol., 11(6), 803-808 (1975); Chem. Abstr., 84, p. 173, Abstract No. 40185e (1976); only Abstract supplied.
K. H. Scheit, "Nucletides with Altered Sugar Parts. Arabino, Xylo and Lyxo Nucleotide Analogs," Ch. 5.1 in Nucleotide Analogs, Synthesis and Biological Function, Wiley-Interscience, New York, 1980, pp. 151-153 and 190-191.

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