Lysosome liberation inhibitors and histamine release inhibitors

Details Lysosome liberation inhibitors and histamine release inhibitors Lysosome liberation inhibitors and histamine release inhibitors

1989-02-10

1990-03-06

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

560231, 560249, C07C 35205, C07C 3305

Patent

active

049067940

ABSTRACT:
The present invention provides lysosome liberation inhibitors comprising, as effective ingredients, cembrane-type diterpene compounds represented by the general formula (I) or (II): ##STR1## wherein R is a hydrogen atom or an acyl group. Also provided is histamine release inhibitors comprising the cembrane-type diterpene compounds represented by the general formula (I) or (II) above as effective ingredients.

REFERENCES:
patent: 4701570 (1987-10-01), Mizusaki et al.
Chem. Abst., 95:169547f, (1981), "Cembrane diterpenes from Sarcophyton Glaucun", Mitsubishi Chem. Ind.
Chem. Abst., 95:169548g, (1981), "Cembrane diterpenes", Mitsubishi Chem. Ind.
Chemical Abstract 92:73002m (1980).
Chemical Abstract 95:150962r (1981).
Chemical Abstract 95:169547f (1981).
Chemical Abstract 95:169548g (1981).

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