Lysophospholipids as biomarkers of ovarian cancer

Details Lysophospholipids as biomarkers of ovarian cancer Lysophospholipids as biomarkers of ovarian cancer

2011-06-21

2011-06-21

Siefke, Sam P (Department: 1772)

Chemistry: analytical and immunological testing

Cancer

Reexamination Certificate

active

07964408

ABSTRACT:
A method of using a bioactive lysophospholipid (LL) as a biomarker for detecting the presence and recurrence of ovarian cancer. Subspecies of LL, such as lysophosphatidic acid (LPA), lysophosphatidylinositol (LPI), lysophosphatidylcholine (LPC), and lysosphingolipid sphinsosine-1-phosphate (S1P), are used alone or in conjunction to increase the specificity and sensitivity of the assay.

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X. Fang et al., “Lysophospholipid Growth Factors in the Initiation, Progression, Me˜stases, and Management of Ovarian Cancer”, Annals New York Academy of Sciences, pp. 188-208.
A. Tokumura, “Physiological and Pathophysiological Roles of Lysophosphatidic Acids Produced by Secretory Lysophospholipase D in Body Fluids”, Biochimica et Biophysica Acta, 1982, (2002), pp. 18-25.
K. Sawada, et al., ˜Lysophosphatidic Acid Induces Focal Adhesion Assembly Through Rho/Rho-Associated Kinase Pathway in Human Ovarian Cancer Cells, Gynecologic 87, 252-259 2002.
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