Lysophosphatidic acid receptor

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S004000, C435S007100

Reexamination Certificate

active

07666611

ABSTRACT:
It is intended to provide a novel receptor of LPA and a method of screening a drug such as an LPA receptor antagonist using the same. Use as a lysophosphatidic acid (LPA) receptor comprising a G protein-coupled protein p2y9. More specifically, use of the G protein-coupled protein p2y9 as a lysophosphatidic acid (LPA) receptor. A method of screening an agonist or an antagonist to the LPA receptor as described above by using the receptor.

REFERENCES:
patent: 853126 (1998-07-01), None
patent: WO-02/053737 (2002-07-01), None
patent: WO-02/061087 (2002-08-01), None
patent: WO-02/068591 (2002-09-01), None
Noguchi et al., Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. J. Biol. Chem. I278:25600-25606, Jul. 11, 2003.
Brian F. O'Dowd, et al., Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes, Gene, 1997, vol. 187, pp. 75-81 & SwissProt database Accession N. Q99677.
Rodolphe Janssens, et al., Cloning of a Human Heptahelical Receptor Closely Related to the P2Y5 Receptor, Blochem, Biophysics, Res. Comm., 1997, vol. 236, pp. 106-112 & SwissProt database Accession No. Q99677.
International Search Report mailed on Mar. 30, 2004.
International Preliminary Examination Report mailed on Jan. 28, 2005.
English translation of International Preliminary Examination Report for PCT/JP2003/016176 mailed on Jul. 28, 2005.
Noguchi et al., “Identification of P2Y9/GPR23 As a Novel G Protein-Coupled Receptor for Lysophosphatidic Acid, Structurally Distant from the EDG Family”, The Journal of Biological Chemistry, vol. 278, No. 28, Jul. 11, 2003, pp. 25600-25606, XP002357510.
Supplementary European Search Report dated Dec. 22, 2005.
European Office Action dated Jan. 15, 2007 for corresponding Application No. 03 780 842.5-2401.

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