Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Patent
1982-05-06
1984-10-02
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
A61K 3578
Patent
active
044747721
ABSTRACT:
Trypanosoma cruzi, a protozoan parasite and the causative agent of Chagas' disease (producing chronic symptoms such as cardiomyopathy with heart failure and arrythmia), are lysed within 24 hours by an extracellular substance produced by Pseudomonas fluorescens. This substance, antitrypanosome factor (ATF-II) of a molecular weight approximately 1,000, actively kills the parasites at doses not toxic on mammals such as mice.
REFERENCES:
Merck Manual 12th ed. 1972, Trypanosomasis pp. 200-201.
Colon-Whitt Alba
Mercado Teresa I.
Goldberg Jerome D.
Roberts, Jr. John S.
Rollins John W.
The United States of America as represented by the Department of
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