Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Multienzyme complexes or mixtures of enzymes
Patent
1989-05-02
1991-10-08
Dees, Jose G.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Multienzyme complexes or mixtures of enzymes
424 9463, 424 9464, 435215, A61K 3754
Patent
active
050552953
ABSTRACT:
The thrombolytic effect of the plasminogen activator pro-urokinase is improved synergistically by the co-administration of urokinase. The two components may be administered sequentially or simultaneously, and if simultaneously, either separately or as a mixture. Preferably an initial bolus injection of urokinase is followed by an infusion of pro-urokinase.
REFERENCES:
patent: Re32271 (1986-10-01), Husain et al.
patent: 3926727 (1975-12-01), Vairel et al.
patent: 4286063 (1981-08-01), Suyama
Lijnen et al., The Journal of Biological Chemistry, vol. 261, No. 3, Jan. 25, 1986, pp. 1253-1258.
Wun et al., The Journal of Biological Chemistry, vol. 257, No. 12, Jun. 25, 1982, pp. 7262-7268.
Gurewich et al., J. Clin. Invest., vol. 73, Jun. 1984, pp. 1731-1739.
Wun et al., The Journal of Biological Chemistry, vol. 260, No. 8, Apr. 25, 1985, pp. 5061-5066.
Collen et al., Biological Abstracts, vol. 79, No. 11, Abs. 98147, Jun. 1, 1985.
Collen et al., Biological Abstracts, vol. 80, No. 9, Abs. 79943, Nov. 1, 1985.
Van de Werf et al., Biological Abstracts, vol. 81, No. 12, Abs. 114481, Jun. 15, 1986.
Matsuo et al., Biological Abstracts, vol. 82, No. 2, No. 2, Abs. 16231, Jul. 15, 1986.
Gurewich et al., Thrombosis Research, vol. 44, No. 2, pp. 217-228, Jul. 1986.
Pannell et al., Biological Abstracts, vol. 82, No. 3, Abs. 30970, Aug. 1, 1986.
Conference Abstract, San Diego, Jul. 1985, 0722, (Gurewich et al.).
Conference Abstract, Paris, Oct. 1985, (Guerwich).
Conference Abstract, Los Angeles, Feb. 1986, E3, (Collen).
Conference Abstracts, Vienna, Aug. 25-29, 1986, 212, (Nguyen), 213, (Collen), 219, (Gurewich et al.) and 227 (Verstraete).
Gurewich, conference notes read at Jul. 1985, San Diego Conference, (see reference AR).
Welzel Dieter
Wolf Helmut
Clarke Vera C.
Dees Jos,e G.
Vascular Laboratory Inc.
LandOfFree
Lysis of fibrin blood clots with urokinase and pro-urokinase does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Lysis of fibrin blood clots with urokinase and pro-urokinase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lysis of fibrin blood clots with urokinase and pro-urokinase will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-256026