Lysis chamber for use in an assay device

Details Lysis chamber for use in an assay device Lysis chamber for use in an assay device

1997-10-02

2000-08-22

Chin, Christopher L.

Chemical apparatus and process disinfecting, deodorizing, preser

Analyzer, structured indicator, or manipulative laboratory...

Calorimeter

422 53, 422 57, 422 58, 422 61, 422 62, 422 73, 422102, 422122, 422145, 422 681, 436169, 436170, 436 52, 436 63, 436164, 436522, 436524, 436809, 4352871, 4352872, 4352891, 4352887, 424 3, G01N 2100, G01N 130, C12M 100, H01L 2114

Patent

active

061067792

ABSTRACT:
A lysis chamber of an assay device capable of producing lysis of cells in a sample fluid such as whole blood, said chamber comprising a surface which contacts the sample fluid when the sample fluid is placed into the assay device; and a lytic material immobilized on the surface, whereby cells of the sample fluid are lysed when they contact the lytic material. The chamber can delimit a capillary space, and lytic material can be saponin or a detergent. Methods employing devices comprising such chambers can assay for whole blood amounts of cyclosporin or hemoglobin A1c.

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Effenhauser et al. High-Speed Separation of Antisense Oligonucleotides on a Micromachined Capillary Electrophoresis Device. Analytical Chemistry vol. 66, No. 18, Sep. 15, 1994, pp. 2949-2953.

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