Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1998-06-03
1999-08-03
Russel, Jeffrey E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 16, 514 17, 530328, 530329, 530330, 530332, A61K 3808
Patent
active
059325488
ABSTRACT:
The present invention relates a number of different lysine containing peptides which can be administered to a mammal to normalize cardiac pressure for treatment of heart disease conditions such as myocardial ischemia. These peptides include certain known peptides, some of which are capable of liberating growth hormone to various degrees when administered to a mammal. Other peptides useful in the invention are novel peptide sequences which include a spirolactam, bicyclic or tricyclic peptidomimetic unit. The peptides disclosed herein exhibit binding to cardiac tissue and normalize cardiac pressure after administration, thus imparting cardiac protecting activity by a mechanism which at the present is unknown. One common feature of the peptides of this invention is that at least one lysine unit is present.
REFERENCES:
patent: 5661122 (1997-08-01), Clark et al.
patent: 5668254 (1997-09-01), Deghenghi
patent: 5798102 (1998-08-01), McMichael et al.
C. Bowers, "Xenobiotic Growth Hormone Secretagogues: Growth Hormone Releasing Peptides" in Bercu BB, Walker RF editors, Growth Hormone Secretagogues, New York: Springer-Verlag, pp. 9-28 (1996).
V. De Gennaro Colonna, "Cardiac ischemia and impairment of vascular endothelium function in hearts from growth hormone-deficient rats: Protection by hexarelin", European Journal of Pharmacology, 334:201-207 (1997).
R. Deghenghi, "Small Peptides as Potent Releasers of Growth Hormone", Journal of Pediatric Endocrinology & Metabolism, 8:311-313 (1995).
R. Deghenghi, "The development of `impervious peptides` as growth hormone secretagogues", Acta Paediatr. Suppl., 423:85-7 (1997).
K. Veeraragavan et al., "Growth Hormone-Releasing Peptide (GHRP) Binding to Porcine Anterior Pituitary and Hypothalamic Membranes", Life Sciences, 50:1149-1155 (1992).
LandOfFree
Lysine containing peptides for treatment of heart disease does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Lysine containing peptides for treatment of heart disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lysine containing peptides for treatment of heart disease will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-849472