Lysine 4-allyloxy-3-chlorophenylacetate and method of its prepar

Details Lysine 4-allyloxy-3-chlorophenylacetate and method of its prepar Lysine 4-allyloxy-3-chlorophenylacetate and method of its prepar

1979-02-21

1980-02-19

Thomas, Jr., James O.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

26050111, C07C10104, A61K 31205

Patent

active

041894995

ABSTRACT:
Lysine 4-allyloxy-3-chlorophenylacetate is a salt of Alclofenac which is soluble in biological fluids and particularly adapted for intravenous or intramuscular administration. Its method of preparation consists in reacting Alclofenac with lysine carbonate in hydroalcoholic solution and separating the corresponding salt by adding precipitants or by concentrating the hydroalcoholic solution.

REFERENCES:
patent: 3658889 (1972-04-01), Suverkropp
patent: 3824277 (1974-07-01), Buu-Hoi et al.
Martin, Remington's Pharm. Sciences, Mack Publishing Co., pp. 180-181 (1965).

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