Lys-Thr dipeptides and their use

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Reexamination Certificate

active

07977308

ABSTRACT:
Dipeptides and derivatives and analogs, such as Pal-KT have been developed. These dipeptides, derivatives and analogs may be used alone or in an additive, to produce cosmetics, topical pharmaceuticals and personal care products, particularly for skin care. Methods of making the dipeptides, derivatives, analogs and additives containing same are also described.

REFERENCES:
patent: 2004/0063628 (2004-04-01), Piccariello et al.
patent: 2 465 123 (2003-05-01), None
patent: WO-03/037933 (2003-05-01), None
Patent Abstract of Japan, vol. 2003, No. 12, & JP 2003 344416 A (National Institute of Advanced Industrial & Technology), Dec. 3, 2003.
Morozova et al., “Synthesis of a fragment of a polymyxin M lysine analog”, Zhurnal Obshchei Khimii, vol. 37, No. 8, pp. 1764-1766, Aug. 1967.
Isshiki, “Enzymic hydrolysis of cycli peptides I. Enzymic cleavage og colistin”, vol. 11, pp. 210-214, 1962.
Silaev, “Chemistry of polymyxin M. IV Synthesis and properties of possible fragments of polymyxin M”, Zhurnal Obshchei Khitmii, vol. 31, 1961.
International Search Report, PCT/IB2005/001821, dated Dec. 1, 2005.

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