Lyophilizer system

Details Lyophilizer system Lyophilizer system

1997-10-07

1999-09-07

Woo, Jay H.

Gas separation: processes

Degasification of liquid

Plural successive degassing treatments

95247, 95257, 95266, 34 92, 34284, F26B 506

Patent

active

059481447

ABSTRACT:
Apparatus and methods are disclosed for lyophilization of protein and/or pharmaceutical products, wherein said apparatus utilizes a dry vacuum pump for the direct removal of water vapor, rather than a cold trap condenser. A freeze dryer has a vacuum pump which is connected directly to a drying chamber without the use of a cold trap condenser. The exhaust of the vacuum pump is vented directly to atmosphere. Water vapor generated in the process is directly removed from the chamber by the vacuum pump. The apparatus permits lyophilization of pharmaceuticals e.g. antibiotics, vitamins products, vaccines, and biological protein solutions. The dryer operates on a batch basis or may be designed to perform continuous production.

REFERENCES:
patent: 3601901 (1971-08-01), Rader
patent: 3731392 (1973-05-01), Gottfried
patent: 4033048 (1977-07-01), Van Ike
patent: 4251923 (1981-02-01), Kuri
patent: 4468866 (1984-09-01), Kendall
patent: 4561191 (1985-12-01), Parkinson
patent: 4802286 (1989-02-01), Kobayashi et al.
patent: 5131168 (1992-07-01), Rilke et al.

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