Lyophilized polyethylene oxide modified protein and polypeptide

Details Lyophilized polyethylene oxide modified protein and polypeptide Lyophilized polyethylene oxide modified protein and polypeptide

1995-01-12

1996-06-25

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Stablizing an enzyme by forming a mixture, an adduct or a...

424 7805, 424 7831, 424 943, 424 7803, 424 7804, 435 25, 435189, 435192, 514 58, 530410, 536103, C12N 996, A61K 31715, A61K 3726

Patent

active

055299156

ABSTRACT:
Disclosed are lyophilized biologically active proteinaceous compositions containing low diol polyalkylene oxide, such as polyethylene glycol, covalently attached to a biologically active proteinaceous substance and combined with the cryoprotectant cyclodextrin.

REFERENCES:
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patent: 4596795 (1986-06-01), Pitha
patent: 4727064 (1988-02-01), Pitha
patent: 4983586 (1991-01-01), Bodor
patent: 5298410 (1994-03-01), Phillips et al.
patent: 5334382 (1994-08-01), Phillips et al.
Anti-Inflammatory & Pharmacokinetic Properties of Superoxide Dismutase Derivatized with Polyethylene Glycol via Active Esters, Veronese et al, 1983 J. Pharm. Pharmacol. 35, 757-758.
Japanese Patent Application Publication Jan. 1996, 107 (Kokai) Publish Apr. 14, 1989.

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