Lyophilized polyethylene oxide modified protein and polypeptide

Details Lyophilized polyethylene oxide modified protein and polypeptide Lyophilized polyethylene oxide modified protein and polypeptide

1994-01-05

1995-02-14

Lilling, Herbert J.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Stabilized enzymes or enzymes complexed with nonenzyme

435 25, 435188, 435189, 435192, 424 7805, 424 7831, 514 58, 530410, 536103, C12N 996, A61K 31715, A61K 3726

Patent

active

053893816

ABSTRACT:
Disclosed are lyophilized biologically active proteinaceous compositions containing low diol polyalkylene oxide, such as polyethylene glycol, covalently attached to a biologically active proteinaceous substance and combined with the cryoprotectant cyclodextrin.

REFERENCES:
patent: 4179337 (1979-12-01), Davis et al.
patent: 4596795 (1986-06-01), Pitha
patent: 4727064 (1988-02-01), Pitha
patent: 4983586 (1991-01-01), Bodor
patent: 5006333 (1991-04-01), Saifer et al.
patent: 5298410 (1994-03-01), Phillips et al.
patent: 5334382 (1994-08-01), Phillips et al.
Anti-Inflammatory & Pharmacokinetic Properties of Superoxide Dismutase Derivatized with Polyethylene Glycol via Active Esters, Veronese et al, 1983 J. Pharm. Pharmacol. 35, 757-758.
Japanese Patent Application Publication 1-96, 107 (Kokai).

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