Lyophilized platelet composition containing chloroquine, hydroxy

Details Lyophilized platelet composition containing chloroquine, hydroxy Lyophilized platelet composition containing chloroquine, hydroxy

1997-08-21

2000-10-03

Saucier, Sandra E.

Chemistry: molecular biology and microbiology

Maintaining blood or sperm in a physiologically active state...

424 9372, A01N 102, A01N 6300

Patent

active

06127111&

ABSTRACT:
The present invention relates to preparations of functionally active platelets and to a process for stabilizing these functionally active platelets by means of freeze-drying. In particular, a lyophilized or reconstituted platelet composition containing an anticoagulant, an cake forming agent ad an inhibitor of platelet function selected from the group consisting of chloroquine, hydroxychloroquine, camoquin, quinacrine and procaine is disclosed.

REFERENCES:
patent: 4405719 (1983-09-01), Crews et al.
patent: 5213814 (1993-05-01), Goodrich, Jr. et al.
patent: 5641637 (1997-06-01), Hudak et al.
patent: 5651966 (1997-07-01), Read et al.
patent: 5736313 (1998-04-01), Spargo et al.
Murakami et al., "Potentiating Effect of Adenosine on Other Inhibitors of Platelet Aggregation", Thrombosis et Diathesis Haemorrahagica 27(2) : 252-62 (1972).
Lehninger, "Biochemistry" Third Edition, Chapter 11, p. 217 (1971).
Glusa et al., "Platelet functions in recombinant hirudin-anticoagulated blood", Haemostasis 20 (2) : 112-8 (1990).
Bode et al., "The use of thrombin inhibitors and aprotinin in the preservation of platelets stored for transfusion" J. Lab. Clinical Med. 113 (6) : 753-8 (1989).
Prowse et al., "Prevention of the platelet alpha-granule release reaction by membrane-active drugs", Thrombosis Research 25 (3) : 219-27 (1982).
Abernathy et al.;"Pooled Donor Control For Platelet Aggregometry" Thrombos. Haemostas. (Stuttg.), 39, p. 246 (1978).
Greinacher et al.; "A Rapid and Sensitive Test for Diagnosing Heparin-Associated Thrombocytopenia" Thrombosis and Haemostasis 66(6), (Sututtgart) pp. 734-736 (1991).
Greinacher et al.; "Laboratory Diagnosis of Heparin-associated Thrombocytopenia and Comparison of Platelet Aggregation Test, Heparin-induced Platelet Activation Test, and Platelet Factor 4/heparin Enzyme-linked immunosorbent Assay" Transfusion; vol. 34, No. 5, pp. 381-385, (1994).
Jackson et al.; "Management of Thrombocytopenia" Haemostasis and Thrombosis, [Colman et al.] J. B. Lipincott Co., 2nd Ed. Chapter 28, pp. 530-536 (1987).
White; Drug Treatment and Prevention of Malaria; "European Journal of Clinical Pharmacology" 34(1), pp. 1-14 (1988).
Bode et al., "The Use of Inhibitors of Platelet Activation or Protease Activity in Platelet Concentrates Stored for Transfusion", Blood Cells, 18, pp. 361-380 (1992).

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