Lyophilized phosphorylated nucleosides

Details Lyophilized phosphorylated nucleosides Lyophilized phosphorylated nucleosides

1981-02-17

1983-09-13

Hazel, Blondel

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 28, 536 29, C07H 1920, C07H 1910

Patent

active

044043686

ABSTRACT:
Phosphorylated nucleotides for addition to nucleotide chains in the stepwise synthesis of oligonucleotides, e.g. as a polymeric support, are prepared in dioxane solvent and then lyophilized, to provide a stable, dry product ready for re-dissolving in reaction solvent. The lyophilized products are stable indefinitely and do not suffer from decreased reactivity.

REFERENCES:
patent: 3338882 (1967-08-01), Wechter
patent: 3433782 (1969-03-01), Kreiser
Letsinger, R., and Lunsford, W., J. Am. Chem. Soc., vol. 90, pp. 3655-3661, 1976.
Matteucci, M. and Caruthers, M., Tetrahedron Letters, vol. 21, pp. 719-722, 1980.
Letsinger, R., J. Am. Chem. Soc., vol. 97, pp. 3278-3279, 1975.
Fieser, L. et al., "Reagents for organic synthesis", vol. 1, p. 333, 1967.

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