Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1987-01-09
1989-02-28
Gerstl, Robert
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540222, A61K 31545, C07D50146
Patent
active
048086177
ABSTRACT:
Amorphous solid formed by lyophilization or cosolvent precipitation of an aqueous solution of 7-[.alpha.-(2-aminothiazol-4-yl)-.alpha.-(Z)-methoximinoacetamido]-3-[(1-m ethyl-1-pyrrolidinio)-methyl[-3-cephem-4-carboxylate zwitterion and a salt or mixture of salts from a selected particular group is a broad spectrum antibiotic composition and has better temperature stability at least up to 45.degree. C. than the zwitterion. The salt is one wherein the cation is selected from the group consisting of sodium, lithium, calcium, and magnesium and the anion is selected from the group consisting of chloride, bromide, and iodide. The molar ratio of zwitterion to salt ranges from about 0.5:1 to about 2:l.
REFERENCES:
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patent: 4406899 (1983-09-01), Aburaki et al.
patent: 4604386 (1986-08-01), Spry
Kessler et al., "Comparison of a New Cephalosporin, BMY-28142, with Other Broad-Spectrum .beta.-Lactam Antibiotics", Antimicrobial Agents and Chemotherapy, vol. 27, No. 2, pp. 207-216, Feb. 1985.
Bogardus Joseph B.
Kaplan Murray A.
Palepu Nageswara R.
Bristol-Myers Company
Gerstl Robert
Morse David M.
Noel Mark W.
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