Lyophilized hepatitis B vaccine

Details Lyophilized hepatitis B vaccine Lyophilized hepatitis B vaccine

1985-03-08

1987-12-01

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Lymphokine

A61K 3929

Patent

active

047103787

ABSTRACT:
Lyophilized preparation of hepartitis B vaccine, which comprises a purified hepatitis B virus surface antigen produced by a recombinant organism being capable of producing HBs antigen, which is adsorbed on aluminum gel in the lyophilized state in the presence of a stabilizer, said lyophilized preparation being prepared by the steps of adding an aluminum gel and a stabilizer to a purified recombinant-origin HBs antigen and lyophilizing the mixture. Said lyophilized preparation being able to be stably kept for a long period of time without losing its antigen titer and being useful for the prophylaxis of infection of hepatitis B virus.

REFERENCES:
patent: 4164565 (1979-08-01), Prince et al.
patent: 4565697 (1986-01-01), Ohmura et al.
Valenzuela et al., Cold Spring Harbor Laboratory Modern Approches to Vaccs, pp. 209-213, 1984.
Valenzuela et al., Nature, vol. 298, pp. 347-350, 1982.

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