Lyophilized cyclophosphamide

Details Lyophilized cyclophosphamide Lyophilized cyclophosphamide

1984-03-13

1985-08-27

Meyers, Albert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514960, A61K 3166

Patent

active

045378835

ABSTRACT:
A lyophilized pharmaceutical solid composition containing cyclophosphamide for reconstitution with water to provide a solution for oral or parenteral administration. This lyophilized cyclophosphamide solid composition demonstrates improved stability, solubility characteristics and enhanced appearance compared with currently available dry powder pre-mix compositions of cyclophosphamide. The lyophilized solid composition contains about 20 parts by weight of cyclophosphamide, about 11/4-2 parts by weight of water and from about 10-85 parts by weight of excipient which is comprised mainly of mannitol. Processes for making the composition are disclosed.

REFERENCES:
patent: 3018302 (1962-01-01), Arnold et al.
patent: 3732340 (1973-05-01), Arnold et al.
Lachman et al., "The Theory And Practice Of Industrial Pharmacy" pp. 521-524 2d Ed., Lea And Febiger Publishers (1976) (Lachman et al.).
"Remington's Pharmaceutical Sciences" pp. 1483-1485 Mack Publishing Co. (1975) (Remington).
Brooke, et al., American Journal Of Hospital Pharmacy, 32:44-45 (1975).

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