Lyophilized composition containing S(+)-4,4'-(1-methyl-1,2-ethan

Details Lyophilized composition containing S(+)-4,4'-(1-methyl-1,2-ethan Lyophilized composition containing S(+)-4,4'-(1-methyl-1,2-ethan

1997-04-10

1998-06-02

Grumbling, Matthew V.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544357, C07D40302, A61K 31495

Patent

active

057600392

ABSTRACT:
A process of making a stable lyophilized, white to off-white, crack-free preparation of ICRF-187 in which the cake of ICRF-187 is protected against the deleterious effect of light, has a moisture content of not more than about 2% wherein the process comprises lyophilization using a starting solution of a therapeutically acceptable acid salt of ICRF-187 having a concentration of up to about 25 mg/ml and in which the primary drying stage lasts at least 30 hours, preferably at least 40 hours, and/or uses a primary drying temperature of from about 30.degree. C. to about 40.degree. C.

REFERENCES:
patent: 3941790 (1976-03-01), Creighton
patent: 4963551 (1990-10-01), Palepu
Martindale, The Extra Pharmacopoeia, Twenty-eighth Edition (1982) p. 225.
Repta A., et al., J. of Pharm. Sciences (1976) 65(2):238-242.
Martindale, The ExtraPharmacopoeia, 28th edition, The Pharmaceutical Press, London (1982).

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