Lyophilized cefepime dihydrochloride for parenteral use

Details Lyophilized cefepime dihydrochloride for parenteral use Lyophilized cefepime dihydrochloride for parenteral use

1990-12-20

1992-03-10

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540222, C07D50100, C07D50114, A61K 31545

Patent

active

050950118

ABSTRACT:
A stable, amorphous, lyophilized dihydrochloride salt of 7-[.alpha.-(2-aminothiazol-4-yl)-.alpha.-(z)-methoxyiminoacetamido]-3-[(1- methyl-1-pyrrolidinium) methyl]-3-cephem-4-carboxylate is described. This lyophilized salt is more easily prepared than the crystalline counterpart and can be reconstituted in effective concentrations for intramuscular and intravenous injection utilizing suitable organic and inorganic bases to pH 3-7.0.

REFERENCES:
patent: 4406899 (1983-09-01), Aburaki et al.
patent: 4808617 (1989-02-01), Kaplan et al.
patent: 4910301 (1990-03-01), Kaplan et al.

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