Refrigeration – Processes – Fractionally solidifying a constituent and separating the same
Reexamination Certificate
2006-07-11
2006-07-11
Doerrler, William C. (Department: 3744)
Refrigeration
Processes
Fractionally solidifying a constituent and separating the same
C062S052100, C062S540000, C062S541000, C034S288000, C210S808000
Reexamination Certificate
active
07073349
ABSTRACT:
A method and apparatus for producing particles, the apparatus includes a solution source that supplies a solution, and a fluid source that supplies a fluid. The solution includes a solvent and a solute. A mixer receives the solution and the fluid from the sources, and mixes the solution and the fluid together to form a mixture. The mixture is supplied from the mixer to an expansion assembly at first pressure. The expansion assembly sprays and expands the mixture substantially simultaneously to form frozen droplets, and preferably to form a low-density powder of frozen droplets. A freeze-dry apparatus sublimes the solvent from the particles. A high mass-transfer rate and a uniform open-structure of the powder bed enhances the freeze-drying process. Solid particles having a controlled size distribution are obtained. The particles preferably have a hollow or porous morphology suitable for differing drug delivery applications to include aerosol formulations.
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Chattopadhyay Pratibhash
Seitzinger Jeffrey S.
Shekunov Boris Y.
Doerrler William C.
Ferro Pfanstiehl Laboratories, Inc.
Rankin, Hill Porter & Clark LLP
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