Receptacles – Receptacle having flexible – removable inner liner – Means for venting air trapped between the liner and its...
Patent
1988-03-24
1989-11-07
Stinson, Frankie L.
Receptacles
Receptacle having flexible, removable inner liner
Means for venting air trapped between the liner and its...
220410, 422102, 249 82, 249153, 249 65, 249183, 62345, B65D 2000
Patent
active
048785970
ABSTRACT:
The invention provides containers useful for freezedrying of biological and other materials which can be advantageously subjected to a lyophilization process, such materials including proteinaceous materials from which moisture is removed in order to preserve the material in a dry, shelf-stable form. The present containers allow lyophilization of the contained material with a minimum of time and energy expenditure by forming the material into a frozen shell to increase the surface area of the material and to minimize the thickness of a given quantity of material which is to be lyophilized. In a typical embodiment of the invention, a container is provided with a congruent, flexible core which is inserted into the container to force the material into the space lying between the container and the core. Expansion of the material on freezing acts to deform the flexible core rather than to break the container. The material thus frozen into a shell-like conformation within the container is then subjected to a lyophilization process after removal of the flexible core.
REFERENCES:
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patent: 2081428 (1937-05-01), Geyer
patent: 3464798 (1969-09-01), Kiltnau
patent: 3898046 (1975-08-01), Ikeda et al.
patent: 4495151 (1985-01-01), Ohyama et al.
Darnell Kenneth E.
Stinson Frankie L.
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