Lymphotoxin DNA, lymphotoxin expression vector

Details Lymphotoxin DNA, lymphotoxin expression vector Lymphotoxin DNA, lymphotoxin expression vector

1986-07-03

1991-01-29

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Vector, per se

536 27, 4351723, 935 36, 935 27, C12N 1500, C12N 1519, C12N 1563, C12N 1567

Patent

active

049886240

ABSTRACT:
A chromosomal DNA sequence which codes for human lymphotoxin, a lymphotoxin expression vector which contains a DNA sequence wherein a chromosomal DNA sequence coding for human lymphotoxin and promoter region which functions in animal cell are linked together, lymphotoxin resistant cell line, transformed animal cell culture which is formed by transforming cultured animal cell with a lymphotoxin expression vector which contains a chromosomal DNA sequence coding for human lymphotoxin and, a process for preparing human lymphotoxin, which comprises transforming cultured animal cell with a lymphotoxin expression vector which contains a chromosomal DNA sequence coding for human lymphotoxin, culturing the transformed cell culture to produce human lymphotoxin, and collecting the human lymphotoxin.
According to the present invention, LT which is expected for application as the antitumor agent can be produced effectively in a large amount.

REFERENCES:
patent: 4727028 (1988-02-01), Santerre et al.
patent: 4740461 (1988-04-01), Kaufman
Wickner, in The Molecular Biology of the Yeast Saccharomyces CSH, 1981, pp. 415-439.
Cloning and Expression of cDNA for Human Lymphotoxin, a Lymphokine with Tumor Necrosis Activity, Gray et al., Nature, vol. 312 20/27 Dec., 1984, pp. 721-724.

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