Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-06-07
1997-08-26
Elliott, George C.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4352402, 536 235, C12N 1500, C12N 1511, C12N 1585
Patent
active
056610041
ABSTRACT:
This invention relates to lymphotoxin-.beta., a lymphocyte membrane type protein. This protein is found on the surface of a number of cells, including phorbol ester (PMA) stimulated T cell hybridoma II-23.D7 cells. This invention also relates to complexes formed between lymphotoxin-.beta. and other peptides such as lymphotoxin-.alpha. and to complexes comprising multiple subunits of lymphotoxin-.beta.. These proteins and complexes are useful in holding LT-.alpha. formed within the cell on the cell surface where the LT-.alpha./LT.beta. complex may act as an inflammation regulating agent, a tumor growth inhibiting agent, a T cell inhibiting agent, a T cell activating agent, an autoimmune disease regulating agent, or an HIV inhibiting agent. Furthermore, the antitumor activity of the LT-.alpha./LT-.beta. complex may be delivered to tumor cells by tumor infiltrating lymphocytes (TILs) transfected with the gene for LT-.beta..
REFERENCES:
patent: 4338397 (1982-07-01), Gilbert et al.
patent: 4758549 (1988-07-01), Mitsuhashi et al.
patent: 4822605 (1989-04-01), Powell
patent: 4849509 (1989-07-01), Thurin et al.
J.L. Browning et al., J. Immunol. 147:1230-7 Aug. 15, 1991.
M.J. Androlewicz et al. J. Biol. Chem. 267(4):2542-7 Feb. 5, 1992.
Y. Abe, et al., "Expression of Membrane-associated Lymphotoxin/Tumor Necrosis Factor-.beta. on Human Lymphokine Killer Cells," Jpn. J. Canc. Res., 82, 23-26 (1991).
Y. Abe et al., "Studies Of Membrane Associated And Soluble (Secreted) Lymphotoxin In Human Lymphokine-Activated T-Killer Cells In Vitro," Lymphokine and Cytokine Research, 11, pp. 115-121 (1992).
Abersold et al., "Internal Amino Acid Sequence Analysis of Proteins Separated By One or Two Dimensional Gel Electrophoresis After In Situ Protease Digestion On Nitrocellulose," PNAS, 84 pp. 6970-6974 (1987).
B. Aggarwal et al., "Primary Structure of Human Lymphotoxin Derived From 1788 Lymphoblastoid Cell Line," J. Biol. Chem., 260, pp. 2334-2344 (1985).
M. Akashi et al., "Lymphotoxin: Stimulation and Regulation of Colony-Stimulating Factors in Fibroblasts," Blood, 74, pp. 2383-2390 (1989).
W.F. Anderson, "Human Gene Therapy," Science, 256, pp. 808-813 (1992).
U. Andersson et al., "Characterization of Individual Tumor Necrosis Factor .alpha.- and .beta.-Producing Cells After Polyclonal T Cell Activation," J. of Immun. Meth., 123, pp. 233-240 (1989).
J.S. Andrews et al., "Characterization of the Receptor for Tumor Necrosis Factor (TNF) and Lymphotoxin (LT) on Human T Lymphocytes," J. Immun., 144, pp. 2582-2591 (1990).
Androlewicz et al., "Lymphotoxin Is Expressed As A Heteromeric Complex With A Distinct 33 kDa Glycoprotein On The Surface Of An Activated Human T-Cell Hybridoma," Journal Of Biological Chemistry, 267, pp. 2542-2547 (1992).
R. Armitage et al., "Molecular And Biological Characterization of A Murine Ligand For CD40," Nature, 357, pp. 80-82 (1992).
K. Badenhoop et al., "TNF-.alpha. Gene Polymorphisms In Type 1 (Insulin-Dependent) Diabetes Mellitus," Diabetologia, 32, 445-448 (1989).
B. Beutler et al., "The History, Properties, and Biological Effects of Cachectin," Biochemistry, 27, pp. 7575-7582 (1988).
T. Bringman et al., "Monoclonal Antibodies to Human Tumor Necrosis Factors .alpha. and .beta.: Application for Affinity Purification, Immunoassays, and as Structural Probes," Hybridoma, 6, pp. 489-507 (1987).
J. Browning et al., "Studies On The Differing Effects Of Tumor Necrosis Factor And Lymphotoxin On The Growth Of Several Human Tumor Lines," J. Immun., 143, pp. 1859-1867 (1989).
J. Browning et al., "Lymphotoxin And An Associated 33 kDa Glycoprotein Are Expressed On The Surface Of An Activated Human T-Cell Hybridoma," J. Immunol., 147, pp. 1230-1237 (1991).
D. Cavender et al., "Endothelial Cell Activation Induced By Tumor Necrosis Factor And Lymphotoxin," Amer. J. Path., 134, pp. 551-560 (1989).
R. Cotran et al., "Endothelial Activation, Its Role in Inflammatory and Immune Reactions," Endothelial Cell Biology, pp. 335-347 (1988).
N. Damle et al., "Distinct Regulatory Effects of IL-4 and TNF-.alpha. During CD3-Dependent and CD3-Independent Initiation Of Human T-Cell Activation," Lymph Res., 8, pp. 85-97 (1989).
M. Eck et al., "The Structure Of Tumor Necrosis Factor-.alpha. At 2.6.ANG. Resolution, Implications For Receptor Binding," J. Biological Chemistry, 264, 29, pp. 17595-17605 (1989).
M. Eck et al., "The Structure of Human Lymphotoxin (Tumor Necrosis Factor-.beta.) At 1.9-.ANG. Resolution," J. Biological Chemistry, 267, 4 pp. 2119-2122 (1992).
T. Farrah et al., "Emerging Cytokine Family," Nature, 358, p. 26 (1992).
G. Fuh et al., "Rational Design Of Potent Antagonists To The Human Growth Hormone Receptor," Science, 256 pp. 1677-1680 (1992).
D. Goeddel et al., "Tumor Necrosis Factors: Gene Structure and Biological Activities," Cold Sprinq Harbor Symposia on Quant. Biol., 51, pp. 597-609 (1986).
G. A. Granger et al., "Lymphocyte In Vitro Cytotoxicity: Mechanisms Of Immune And Non-Immune Small Lymphocyte Mediated Target L Cell Destruction," Jour. of Immun., 101, pp. 111-120 (1968).
P. Gray, "Molecular Characterization of Human Lymphotoxin," Lymphokines, 13, pp. 199-208 (1987).
P. Gray et al., "Cloning and Expression of cDNA For Human Lymphotoxin, A Lymphokine With Tumor Necrosis Activity," Nature, 312, pp. (721-724) (1984).
L. Green et al., "Cytotoxic Lymphokines Produced By Cloned Human Cytotoxic T Lymphocytes," J. of Immun., 135, pp. 4034-4043 (1985).
L. Green et al., "Rapid Colorimetric Assay for Cell Viability: Application to the Quantitation of Cytotoxic and Growth Inhibitory Lymphokines," J. of Immun. Meth., 70, pp. 257-268 (1984).
J. Hiserodt et al., "Identification of Membrane-Associated Lymphotoxin (LT) on Mitogen-Activated Human Lymphocytes Using Heterologous Anti-LT Antisera In Vitro," Cell. Immun., 34, pp. 326-339 (1977).
N. Itoh et al., "The Polypeptide Encoded By The cDNA For Human Cell Surface Antigen FAS Can Mediate Apoptosis," Cell 66, pp. 233-243 (1991).
E. Jones et al., "Structure Of Tumor Necrosis Factor," Nature, 338, pp. 225-228 (1989).
A. Kasid et al., "Human Gene Transfer: Characterization of Human Tumor-Infiltrating Lymphocytes As Vehicles For Retroviral-Mediated Gene Transfer In Man," Proc. Natl. Acad. Sci. USA, 87, pp. 473-477 (1990).
M. Kinkhabwala et al., "A Novel Addition To The T Cell Repertory," J. Exp. Med., 171, pp. 941-946 (1990).
M. Kriegler et al., "A Novel Form of TNF/Cachectin Is A Cell Surface Cytotoxic Transmembrane Protein: Ramifications For the Complex Physiology of TNF," Cell, 53, pp. 45-53 (1988).
Liang et al., "Production And Characterization of Monoclonal Antibodies Against Recombinant Human Tumor Necrosis Factor/Cachectin," Biochem. Biophys. Res. Comm., 137, pp. 847-854 (1986).
C. Liu et al., "Identification, Isolation, and Characterization of a Novel Cytotoxin in Murine Cytolytic Lymphocytes," Cell, 51, pp. 393-403 (1987).
C. Liu et al., "Identification and Characterization of a Membrane- bound Cytotoxin of Murine Cytolytic Lymphocytes That is Related to Tumor Necrosis Factor/Cachectin," Proc. Natl. Acad. Sci. USA, 86, pp. 3286-3290 (1989).
B. Luettig et al., "Evidence For The Existence of Two Forms of Membrane Tumor Necrosis Factor: An Integral Protein and a Molecule Attached To Its Receptor," J. Immun., 143, pp. 4034-4038 (1989).
S. Mallett et al., "A New Superfamily Of Cell Surface Proteins Related To The Nerve Growth Factor Receptor," Immunology Today, 12, pp. 220-223 (1991).
L.J. Old, "Tumor Necrosis Factor (TNF)," Science, 230, pp. 630-632 (1985).
N. Paul et al., "Lymphotoxin," Ann. Rev. Immun., 6, pp. 407-438 (1988).
N. Paul et al., "Lymphotoxin Activation by Human T-Cell Leukemia Virus Type I-Infected Cell Lines: Role NF-kB," J. Virol., 64, pp. 5412-5419 (1990).
D. Pennica et al., "Human Tumor Necrosis Factor: Precursor Structure, Expression And Homology To Lymphotoxin," Nature, 312, pp. 724-729 (1984).
A. Peterson et al., "Monoclonal Antibody and Ligand Binding Sites Of The T Cell Erythrocyte Receptor (CD2)," Nature, 329, pp. 842-846 (1987).
F. Pociot et al., "A Tumor Necrosis Factor .beta. Gene Polymorphism In Relation To Monokin
Browning Jeffrey
Ware Carl F.
Biogen Inc.
Elliott George C.
Flynn Kerry A.
Nelson Amy J.
University of California
LandOfFree
Lymphotoxin-.beta., lymphotoxin-.beta. complexes, pharmaceutical does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Lymphotoxin-.beta., lymphotoxin-.beta. complexes, pharmaceutical, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lymphotoxin-.beta., lymphotoxin-.beta. complexes, pharmaceutical will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1987514