Lymphotactin uses

Drug – bio-affecting and body treating compositions – Lymphokine

Patent

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Details

514 2, 514 8, 514 12, A61K 3819

Patent

active

060225343

ABSTRACT:
This invention relates to the use of lymphotactin or lymphotactin antagonists for administration to an animal. The administration of these therapeutic entities will attract certain cell types, or can be blocked to prevent such attraction. It also provides means to protect stem cells.

REFERENCES:
Yoshida et al. FEBS Lett. 360:155-159, 1995.
Maghazachi et al. FASEB J. 11:765-774, 1997.
Dilloo et al. Nature Medicine 2:1090-1095, Oct. 1996.
Kennedy et al. J. Immunol. 155:203-209, 1995.
Marco Baggiolini and Clemens A. Dahinden, Immunology Today, 15(3):127-133, 1994. "CC chemokines in allegic inflammation".
Donald M. Cook, Journal of Leukocyte Biology, 59:61-66, 1996. "The Role of MIP-.alpha.1 in inflammation and hematopoiesis".
Dagmar Dilloo, et al., Nature Medicine, 2(10):1090-1095, Oct. 1996. "Combined chemokine an cytokine gene transfer enhances antitumor immunity".
Brigitte Dorner, et al., Journal of Biological Chemistry, 272(13):8817-8823, 1997. "Purification, Structural Analysis, and Fuction of Natural ATAC, a Cytokine Secreted by CD8+ T Cells".
Bianchi Giancarlo, et al., European Journal of Immunology, 26:3238-3241, 1996. "Migratory response of human natural killer cells to lymphotactin".
G.J. Graham, et al., Nature, 344:442-444, Mar. 29, 1990. "Identification and characterization of an inhibitor of haemopoietic stem cell proliferation".
M.G. Hunter, et al., Blood, 86(12):4400-4408, Dec. 15, 1995. "BB-10010: An Active Variant of Human Macrophage Inflammatory Protein-.alpha.1 With Improved Pharmaceutical Properties".
B.I. Lord, et al., Blood, 79(10):2605-2609, May 15, 1992. "Macrophage Inflammatory Protein Protects Multipotent Hematopoietic Cells From the Cytotoxic Effects of Hydroxyurea in Vitro".
B.I. Lord, et al., Blood, 85(12):3412-3415, Jun. 15, 1995. "Mobilization of Early Hematopoietic Progenitor Cells With BB-10010: A Genetically Engineered Variant of Human Macrophage Inflammatory Protein-.alpha.1".
Azzam A. Maghazachi, et al., FASEB Journal, (11):765-774, Aug. 1997. "Interferon-inducible protein-10 and lymphotactin induce the chemotaxis and mobilization of intracellular calcium in natural killer cells through pertussis toxin-sensitive and -insensitive heterotrimeric G-proteins".
Charlie Mantel, et al., Proc. Natl. Acad. Sci., USA, 90:2232-2236, Mar. 1993. "Polymerization of murine macrophage inflammatory protein 1.alpha. inactivates its myelosuppresive effects in vitro: The active form is a monomer".
Byung-S. Youn, et al., Journal of Immunology, 155:2661-2667, 1995. "A Novel Chemokine, Macrophage Inflammatory Protein-Related Protein-2, Inhibits Colony Formation of Bone Marrow Myeloid Progenitors".

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