Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2006-09-26
2006-09-26
Canella, Karen A. (Department: 1643)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S320100, C435S325000, C435S252300, C435S254110, C536S023500, C536S024500
Reexamination Certificate
active
07112420
ABSTRACT:
The invention provides isolated nucleic acids molecules, designated BBAP nucleic acid molecules, which encode proteins that interact with or bind to BAL molecules, which are differentially expressed in non-Hodgkin's lymphoma. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing BBAP nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a BBAP gene has been introduced or disrupted. The invention still further provides isolated BBAP proteins, fusion proteins, antigenic peptides and anti-BBAP antibodies. Diagnostic methods using compositions of the invention are also provided.
REFERENCES:
patent: WO 00/12698 (2000-03-01), None
patent: WO 00/26231 (2000-05-01), None
patent: WO 01/53453 (2001-07-01), None
patent: WO 01/53453 (2001-07-01), None
Verma et al, Nature, 1997, vol. 389, pp. 239-242.
Eck et al, Gene-Based Therapy, In: The Pharmacological Basis of Therapeutics, Goodman and Gilman, Ed.s, 1996, pp. 77-101.
Orkin et al, “Report and Recommendation of the Panel to Assess the NIH Investment in Research on Gene Therapy”, NIH, 1995.
Accession No. AI274035, NCI-CGAP, Jan. 29, 1999.
New England Biolabs Catalog, 1993-1994, p. 91.
EMBL Acc. No. AC026506 for Homo sapiens chromosome 3 clone RP11-757112 map 3, Working Draft Sequence, 33 unordered pieces.
Aguiar et al. “TEL-AML1 fusion in acute lymphoblastic leukaemia of adults.”Br. J. Haematol.Dec. 1996;95(4):673-677.
Aguiar et al. “PTPROt: an alternatively spliced and developmentally regulated B-lymphoid phosphatase that promotes G0/G1 arrest.”BloodOct. 1, 1999;94(7):2403-2413.
Alizadeh et al. “Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling.”Nature2000;403:503-511.
Bleul et al. “A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1).”J. Exp. Med.Sep. 1, 1996;184(3):1101-1109.
Bretscher “Regulation of cortical structure by the ezrin-radixin-moesin protein family.”Curr. Opin. Cell Biol.Feb. 1999;11(1):109-116.
Burger et al. “Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells.”BloodDec. 1, 1999;94(11):3658-3667.
Cabanillas et al. “Frequent nonrandom chromosome abnormalities in 27 patients with untreated large cell lymphoma and immunoblastic lymphoma.”Cancer Res.Oct. 1, 1988;48(19):5557-5564.
Cigudosa et al., “Cytogenetic analysis of 363 consecutively ascertained diffuse large B-cell lymphomas.”Genes, Chromosomes&Cancer1999;25:123-133.
Costanzi et al. “Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals.”NatureJun. 11, 1998;393(6685):599-601.
Duan et al. “Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations.”PNAS USAJul. 3, 1995;92(14):6459-6463.
Förster et al. “CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.”CellOct. 1, 1999;99(1):23-33.
Freemont et al. “A novel cysteine-rich sequence motif.”CellFeb. 8, 1999;64(3):483-484.
Horwitz et al. “Cell migration-movin' on.”Science1999;286(5442):1102-3.
Khokhar et al. “Cytogenetic abnornalities in the leukemic phase of non-Hodgkin lymphoma.”Cancer Genet. Cytogenet.Aug. 1995;83(1):18-24.
Lankes et al. “Moesin: a member of the protein 4.1-talin-ezrin family of proteins.”PNAS USAOct. 1, 1991:88(19):8297-301.
de Leval et al. “Nodal diffuse large B-cell lymphomas (DLB-CLs) are more likely to be derived from germinal center B-cells than extranodal DLB-CLs.”Blood1999;94:521a.
Liang et al. “Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction.”ScienceAug. 14, 1992;257(5072):967-71.
Lupas “Predicting coiled-coil regions in proteins.”Curr. Opin. Struct. Biol.Jun. 1997;7(3):388-93.
Maloisel et al. “Emergence of unusual cytogenetic abnormalities under interferon-alpha therapy in patients with chronic myelogenous leukemia.”Cancer Genet. Cytogenet.Sep. 1999;113(2):172-6.
Matsuno et al. “Human deltex is a conserved regulator of Notch signalling.”Nat. Genet.May 1998;19(1):74-8.
Mitelman et al. “A breakpoint map of recurrent chromosomal rearrangements in human neoplasia,”Nat. Genet.1997;15 Spec No:417-474.
Monni et al. “Gain of 3q and deletion of 11q22 are frequent aberrations in mantle cell lymphoma.”Genes, Chromosomes, Cancer,Apr. 1998;21(4):298-307.
Nagase et al. “Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.”DNA Res.Oct. 29, 1999;6(5):337-345.
Ohno “Gene duplication and the uniqueness of vertebrate genomes circa 1970-1999.”Semin. Cell Dev. Biol.Oct. 1999;10(5):517-522.
Pampeno et al. “A novel cDNA transcript expressed in fractionated X-irradiation-induced murine thymomas.”Cell Growth&Differentation1996;7:1113-1123.
Pehrson et al. “MacroH2A, a core histone containing a large nonhistone region.”Science.Sep. 4, 1992;257(5075):1398-400.
Pehrson et al. “Evolutionary conservation of histone macroH2A subtypes and domains.”Nucleic Acids Res.Jun. 15, 1998;26(12):2837-2842.
Ren et al. “Identification of a ten-amino acid proline-rich SH3 binding site.”Science.Feb. 19, 1993;259(5098):1157-1161.
Salgia et al. “Expression of the focal adhesion protein paxillin in lung cancer and its relation to cell motility.”OncogeneJan. 7, 1999;18(1):67-77.
Schlegelberger et al. “Clinicopathogenetic significance of chromosomal abnormalities in patients with blastic peripheral B-cell lymphoma. Kiel-Wien-Lymphoma Study Group.”BloodNov. 1, 1999;94(9):3114-3120.
Schouten et al. “Chromosomal abnormalities in untreated patients with non-Hodgkin's lymphoma: associations with histology, clinical characteristics, and treatment outcome.”BloodMay 1, 1990;75(9):1841-1847.
Shipp et al. “A predictive model for aggressive non-Hodgkin's lymphoma.”N. Engl. J. Med.Sep. 30, 1993;329(14):987-994.
Shipp “Prognostic factors in aggressive non-Hodgkin's lymphoma: who has (high-risk) disease?”BloodMar. 1, 1994;83(5):1165-1173.
Shipp “Can we improve upon the International Index?”Ann. Oncol.1997;8 Suppl 1:43-47.
Shipp et al. “Non-Hodgkin's lymphomas.” In DeVita VT, Hellman et al. eds.Cancer Principles&Practice of Oncology,Philadelphia, PA, JB Lippincott Company 1997;2165-2220.
Shipp et al. “International Consensus Conference on High-Dose Therapy with Hematopoietic Stem Cell Transplantation in Aggressive Non-Hodgkin's Lymphomas: report of the jury.”J. Clin. Oncol.Jan. 1999;17(1):423-429.
Smith et al. “Tankyrase, a poly(ADP-ribose) polymerase at human telomeres.”ScienceNov. 20, 1998;282(5393):1484-1487.
Smith et al. Vertebrate genome evolution: a slow shuffle or a big bang.?Bioassays1999;8:697-703.
Testoni et al. “3q21 and 3q26 cytogenetic abnormalities in acute myeloblastic leukemia: biological and clinical features.”HaematologicaAug. 1999;84(8):690-694.
Trentin et al. “The chemokine receptor CXCR3 is expressed on malignant B cells and mediates chemotaxis.”J. Clin Invest.Jul. 1999;104(1):115-21.
Weiss et al. “The mammalian myosin heavy chain gene family.”Annu. Rev. Cell Dev. Biol.1996;12:417-439.
Xiao et al. “FGFR 1 is fused with a novel zinc-finger gene. ZNF198, in the t(8;13) leukaemia/lymphoma syndrome,”Nat. Genet.Jan. 1998;18(1):84-7.
Aguiar Ricardo
Gu Liqun
Shipp Margaret A.
Takeyama Kunihiko
Canella Karen A.
Dana-Farber Cancer Institute
Laccotripe Zacharakis Maria
Smith DeAnn F.
LandOfFree
Lymphoma associated molecules and uses therefor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Lymphoma associated molecules and uses therefor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lymphoma associated molecules and uses therefor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3600347