Lymphocyte chemoattractant factor and uses thereof

Details Lymphocyte chemoattractant factor and uses thereof Lymphocyte chemoattractant factor and uses thereof

1995-06-07

1998-09-15

Walsh, Stephen

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Binds antigen or epitope whose amino acid sequence is...

514 2, A61K 39395, A61K 3819

Patent

active

058075496

ABSTRACT:
Disclosed is a substantially pure antibody which specifically binds a LCF polypeptide and methods of using such antibodies.

REFERENCES:
patent: 4745051 (1988-05-01), Smith et al.
Cruikshank, et al., EMBL Database, Accession No. M90391 (1992).
Center, et al. (Feb. 1995) "The Lymphocyte Chemoattractant Factor", J. Lab. Clin. Med. 125(2):167-172.
Cruikshank, et al. (May 24, 1994) "Molecular and Functional Analysis of a Lymphocyte Chemoattractant Factor: Association of Biologic Function with CD4 Expression", Proc. Natl. Acad. Sci. USA 91(11):5109-5113.
IUIS/WHO Standing Committee on Interleukin Designation (May 1996) "Terminology Note: Interleukin 16 (IL-16)", Eur. J. Immunol. 26(5)1196.
Berman et al., (1991), "Lymphocyte Recruitment to the Lung", Am. Rev. Respir. Dis., vol. 142: 238-257.
Berman et al., (1985), "Chemattractant Lymphokines Specific for the Helper/Inducer T-Lymphocyte Subset", Cellular Immunology, vol. 95: 105-112.
Campbell, Ailsa M., (1984), "Monoclonal Antibody Technology, The Production and Characterization of Rodent and Human Hybridomas", in Laboratory Techniques in Biochemistry and Moleculer Biology Elsevier Science Publishers B.V., vol. 13: 1-4 and 29-32.
Center, et al, (1982), "Modulation of Lymphocyte Migration By Human Lymphokines", The Journal of Immunology, vol. 128, No. 6: 2563-2567.
Cruikshank et al., (1991), "Lymphocyte Chemoattractant Factor Induces CD4-Dependent Intracytoplasmic Signaling in Lymphocytes", The Journal of Immunology, vol. 146, No. 9: 2928-2934.
Cruikshank et al., (1987) "Lymphokine Activation of T4.sup.30 T Lymphocytes and Monocytes", The Journal of Immunology, vol. 138, No. 11: 3817-3823.
Cruikshank et al., (1982) "Modulation of Lymphocyte Migration By Human Lymphokines", The Journal of Immunology, vol. 128, No. 6: 2569-2574.
Rand, et al., (1991), "CD4-mediated Stimulation of Human Eosinophils: Lymphocyte Chemoattractant Factor and Other CD4-binding Ligand Elicit Eosinophil Migration", J. Exp. Med., vol. 173: 1521-1528.

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