Lymphocyte activity regulation by HLA peptides

Details Lymphocyte activity regulation by HLA peptides Lymphocyte activity regulation by HLA peptides

1992-03-02

1999-03-30

Cunningham, Thomas M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Amino acid sequence disclosed in whole or in part; or...

530300, 530324, 530328, 530868, 514 2, 514 12, 514 15, A61K 3800, A61K 3916, C07K 1474

Patent

active

058885129

ABSTRACT:
Fragments from the polymorphic domains of Class I HLA antigen domains are used to modulate T-cell activity. The peptides are from the .alpha.1- or .alpha.2 domains, particularly of the HLA-A, and B antigens. The peptides may be conjugated to other compounds to be used in diagnosis and therapy. The peptides may block lysis, CTL proliferation or have other regulating effects.

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