Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1998-06-15
1999-07-27
Harrison, Robert
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424490, A61K 951
Patent
active
059286695
ABSTRACT:
A composition for delivering an active agent to the lymphatic system comprises a plurality of colloidal particles and an active agent associated with each particle, wherein the surface of each particle has a hudrophobicity ratio as defined of less than 10, or wherein a modifying agent is adsorbed onto the surface of each particle such that the modifying agent gives an advancing contact angle as defined of less than 60.degree. or wherein the adsorbed layer thickness as defined is less than 10 nm or the albumin uptake ratio is between 0.2 and 0.5. The composition may satisfy one or more of these requirements. Preferred modifying agents are non-ionic surfactants, in particular block copolymers containing polyethyleneglycol.
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Christy Nicola
Davis Stanley S.
Illum Lisbeth
Moghimi Moein
Danbiosyst UK Limited
Harrison Robert
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