Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-05-23
1998-07-21
Tsang, Cecilia J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 2, 514800, 530313, 530328, 938110, A61K 3800, A61K 3824, A01N 3718, C04K 500
Patent
active
057835624
ABSTRACT:
A method is provided for the design and synthesis of Leuteinizing Hormone Releasing Hormone (LHRH) antagonists having exact amino acid sequences and containing 5-100 amino acids. This method can be used to produce peptides useful in treating disorders of the reproductive endocrine system, including endometriosis, precocious puberty, prostate cancer and breast cancer. Additionally, peptides produced by this method can be used as contraceptives for either males or females. Peptides produced by this method can further be employed in the diagnosis and treatment of infertility.
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Marvin J. Karten et al., Gonadotropin-Releasing Hormone Analog Design. Structure-Function Studies toward the Development of Agonists and Antagonists: Rationale and Perspective. Vo. 7, No. 1.
Karl Folkers et al., Activities of Antagonists of the Luteinzing Hormone Releasing Hormone with Emphasis on Positions 1, 5 and 6 and on Positions 1, 2 and 3. Z. Naturforsch. 42b, 101-106 (1987); received Jul. 18, 1986.
Karl Folkers et al., Relative Potencies of Antagonists of the Luteinizing Hormone Releasing Hormone with Lys.sup.8 and Arq.sup.8 and Substitutions in Positions 3, 5, 6, 7 and 8. pp. 1087-1091 (1986); received Jun. 10, 1986.
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Asta Medica Aktiengesellschaft
Harle Jennifer
Tsang Cecilia J.
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