Lung tissue extract useful for treating hyaline-membrane disease

Details Lung tissue extract useful for treating hyaline-membrane disease Lung tissue extract useful for treating hyaline-membrane disease

1980-05-21

1982-07-06

Rosen, Sam

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

A61K 3512

Patent

active

043383017

ABSTRACT:
A surface active material may be produced from the lung tissue of mammal by means of employing an acetone-treatment procedure as well as an organic solvents mixture-treatment procedure other than the conventional procedures of differential centrifugation, density gradient centrifugation and dialysis. The chemical composition of the active material has for example, a phospholipid content of 75.0-95.5%, a neutral lipid content of 1.8-14.0%, total cholesterol content of 0.0-3.0%, carbohydrate content is 0.1-1.5% and protein content is 0.5-5.0%, all based on the dried weight of the material. The pharmaceutical composition containing the surface active material defined as above is usable for clinical treatment of human hyaline-membrane disease.

REFERENCES:
King et al., Am. J. of Physiol, vol. 223, No. 3, Sep. 1972, pp. 707-726.
Adams et al., Pediat. Res., vol. 12, (1978), pp. 841-848.
Harwood et al., Biochem. J., vol. 151, (1975), pp. 707-714.
Onophrio, Chem. Abst., vol. 79, (1973), p. 96957x.

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