Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Patent
1988-05-23
1992-11-17
Wax, Robert A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
530399, 530395, 53038824, 5303892, C07K 1514, C07K 1528
Patent
active
051644894
ABSTRACT:
The invention relates to the purification and characterization of growth stimulatory and inhibitory protein factors produced by various organs which appear to play a role in the successful formation of metastatic colonies of tumor cells. In particular, it has been found that syngeneic organs secrete protein growth stimulatory and inhibitory factors which can, at low concentrations, affect metastatic tumor cells. The ability of a malignant cell to respond to these factors is believed to be related to tumor cell metastasis to specific body organs. In particular a lung growth stimulatory glycoprotein having a molecular weight of approximately 66,000 daltons has been found to stimulate growth of lung-metastatic rat and human mammary tumor cells in serum deprived medium.
REFERENCES:
patent: 4670539 (1987-06-01), Sirbasku
Cavanaugh et al. 1989, Cancer Research 49:3928-3933.
Campbell, A. M. 1985, Monoclonal Antibody Technology, In Laboratory Techniques in Biochemistry and Molecular Biology, (eds.) Burdon et al. Elsevier, New York, pp. 66-254.
Abstract, Biosir Number 70001775 of Naum et al. 1979 Inflammation 3(3): 253-260.
Cavanaugh et al., Proceedings of American Association for Cancer Research Annual Meeting, 29:71 (1988).
Nicolson et al., J. Cell Biochem, Suppl. (1989).
Nicolson, Biological Abstracts, 83:10, No. 98591 (1987).
Macaulay et al., Chemical Abstracts 108:148083y (1988).
Nicolson, Garth L., "Differential Growth Properties of Metastatic Large-Cell Lymphoma Cells in Target Organ-Conditioned Medium"; 168 Esp. Cell Res. 572-577 (1987).
Szaniawska, Bozena, et al., "Stimulatory and Inhibitory Activities of Lung-Conditioned Medium on the Growth of Normal and Neoplastic Cells in Vitro"; 75 JNCI no. 2, 303-306 (Aug. 1985).
Kirk, David et al., "Modulation of Growth of a Human Prostatic Cancer Cell Line"; 41 Cancer Research 1100-1103 (Mar. 1981).
Nicolson, Garth L. et al., "Organ Specificity of Metastatic Tumor Colonization is Related to Organ-Selective Growth Properties of Malignant Cells"; 38 Int. J. Cancer, 289-294 (1986).
Cavanaugh Philip G.
Nicolson Garth L.
Board of Regents University of Texas System
Furman Keith C.
Wax Robert A.
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