Lunasin peptides

Details Lunasin peptides Lunasin peptides

2008-05-20

2008-05-20

Wehbe, Anne Marie S. (Department: 1633)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C435S455000, C435S375000, C435S325000

Reexamination Certificate

active

10302633

ABSTRACT:
The invention provides methods and compositions of selectively disrupting mitotic function in a target cell demonstrating undesirable mitotic function. Suitable target cells include mammalian, plant and bacterial cells, which cells may be in vitro or in situ. The general methods involve introducing into the target cell an effective amount of a peptide comprising contiguous acidic amino acids, such as Asp or Glu, whereby the undesirable mitotic function of the cell is selectively disrupted. In particular embodiments, the peptide comprises a Gm2S-1 peptide, particularly a lunasin and/or alisin peptide. The peptide may be introduced by transfecting the cell with a nucleic acid encoding the peptide.

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Sryer L., in Prediction of Conformation From Amino Acid Sequenced. Biochemistry. 1975, W. H. Freeman and Company, New York, p. 37.

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