Lunasin peptides

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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Details

C435S455000, C435S375000, C435S325000

Reexamination Certificate

active

07375092

ABSTRACT:
The invention provides methods and compositions of selectively disrupting mitotic function in a target cell demonstrating undesirable mitotic function. Suitable target cells include mammalian, plant and bacterial cells, which cells may be in vitro or in situ. The general methods involve introducing into the target cell an effective amount of a peptide comprising contiguous acidic amino acids, such as Asp or Glu, whereby the undesirable mitotic function of the cell is selectively disrupted. In particular embodiments, the peptide comprises a Gm2S-1 peptide, particularly a lunasin and/or alisin peptide. The peptide may be introduced by transfecting the cell with a nucleic acid encoding the peptide.

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patent: 5770422 (1998-06-01), Collins
patent: 5850016 (1998-12-01), Jung et al.
patent: 6020202 (2000-02-01), Jessee
patent: 6090577 (2000-07-01), Hillman et al.
Sryer L., in Prediction of Conformation From Amino Acid Sequenced. Biochemistry. 1975, W. H. Freeman and Company, New York, p. 37.

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