Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Means for analyzing liquid or solid sample
Reexamination Certificate
2001-11-30
2008-12-09
Cain, Edward J (Department: 1796)
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
Means for analyzing liquid or solid sample
C526S285000, C252S301350, C422S082080
Reexamination Certificate
active
07462325
ABSTRACT:
This invention involves a series of articles, dispersions, compositions, methods, and kits. Several aspects of the invention involve dispersed particles made from polymers having a delocalized π-orbital backbone structure, as well as methods for making and using such particles. The delocalized π-orbital backbone allows the polymer to have a high degree of luminosity, useful in many embodiments of the invention. The polymers of this invention can also have bulky substituents to prevent intermolecular π-π interactions that can decrease luminosity. The polymer may also have charged side chains immobilized relative to the backbone, which can allow the polymer to be made into stably suspended micro- or nanoparticles dispersed in solution, sometimes with very narrow size distributions. In some embodiments, depending on the conditions used to synthesize and prepare the particles, the particles each consist of a single polymer molecule. Side groups, including biological, biochemical, or chemical molecules, can be attached to the polymer to provide additional functions, such as altering the luminosity of the polymer, or allowing the polymer to bind to certain molecules, such as in a chemical sensor or in a biological assay. As the binding of a molecule to a side group on the polymer can affect the structure of the polymer or alter the luminosity of the particle, the particles of the invention may be used, in certain embodiments, to detect the presence of single molecules.
REFERENCES:
patent: 4356429 (1982-10-01), Tang
patent: 4687732 (1987-08-01), Ward et al.
patent: 4927768 (1990-05-01), Coughlin et al.
patent: 4946890 (1990-08-01), Meador
patent: 4992302 (1991-02-01), Lindmayer
patent: 5155149 (1992-10-01), Atwater et al.
patent: 5194393 (1993-03-01), Hugl et al.
patent: 5236808 (1993-08-01), Smothers
patent: 5244813 (1993-09-01), Walt et al.
patent: 5254633 (1993-10-01), Han et al.
patent: 5364797 (1994-11-01), Olson et al.
patent: 5414069 (1995-05-01), Cumming et al.
patent: 5451683 (1995-09-01), Barrett et al.
patent: 5511547 (1996-04-01), Markle et al.
patent: 5512490 (1996-04-01), Walt et al.
patent: 5532129 (1996-07-01), Heller
patent: 5540999 (1996-07-01), Yamamoto et al.
patent: 5546889 (1996-08-01), Wakita et al.
patent: 5554747 (1996-09-01), Sharma et al.
patent: 5556524 (1996-09-01), Albers
patent: 5563056 (1996-10-01), Swan et al.
patent: 5565322 (1996-10-01), Heller
patent: 5580527 (1996-12-01), Bell et al.
patent: 5585646 (1996-12-01), Kossovsky et al.
patent: 5591787 (1997-01-01), Schlennert et al.
patent: 5597890 (1997-01-01), Jenekhe
patent: 5607864 (1997-03-01), Ricchiero et al.
patent: 5679773 (1997-10-01), Holmes
patent: 5700696 (1997-12-01), Chandross et al.
patent: 5705348 (1998-01-01), Meade et al.
patent: 5709994 (1998-01-01), Pease et al.
patent: 5710197 (1998-01-01), Fischer et al.
patent: 5723218 (1998-03-01), Haugland et al.
patent: 5869592 (1999-02-01), Gagne et al.
patent: 5925517 (1999-07-01), Tyagi et al.
patent: 6020426 (2000-02-01), Yamaguchi et al.
patent: 6259277 (2001-07-01), Tour et al.
patent: 6589731 (2003-07-01), Chen et al.
patent: 6713298 (2004-03-01), McDevitt et al.
patent: 6743640 (2004-06-01), Whitten et al.
patent: 6783814 (2004-08-01), Swager et al.
patent: 7208122 (2007-04-01), Swager et al.
patent: 2002/0040805 (2002-04-01), Swager
patent: 2002/0051985 (2002-05-01), Whitten et al.
patent: 2002/0150697 (2002-10-01), Swager et al.
patent: 2002/0150759 (2002-10-01), Jones et al.
patent: 2002/0177136 (2002-11-01), McBranch et al.
patent: 2003/0054413 (2003-03-01), Kumaraswamy et al.
patent: 2003/0134959 (2003-07-01), Hancock et al.
patent: 2003/0178607 (2003-09-01), Swager et al.
patent: 2004/0043251 (2004-03-01), Epstein et al.
patent: 2004/0121337 (2004-06-01), Deans et al.
patent: 2004/0175768 (2004-09-01), Kushon et al.
patent: 2004/0235184 (2004-11-01), Swager
patent: 2004/0241768 (2004-12-01), Whitten et al.
patent: 2005/0014160 (2005-01-01), Kumaraswamy et al.
patent: 2006/0024707 (2006-02-01), Deans et al.
patent: 197 44 792 (1999-04-01), None
patent: 198 06 037 (1999-08-01), None
patent: 0442123 (1991-08-01), None
patent: 1 011 154 (2000-06-01), None
patent: 06-322078 (1994-11-01), None
patent: WO89/00593 (1989-01-01), None
patent: WO95/16681 (1995-06-01), None
patent: WO99/57222 (1999-11-01), None
patent: WO 01/57140 (2001-08-01), None
patent: WO 02/16463 (2002-02-01), None
patent: WO 03/048226 (2003-06-01), None
patent: WO 2004/057014 (2004-07-01), None
Halkyard, Carrie E., et al., “Evidence of Aggregate Formation for 2,5-Dialkylpoly (p-phenyleneethynylenes) in Solution and Thin Films,” Macromolecules, Nov. 25, 1998, vol. 31, No. 25, pp. 8655-8659, American Chemical Society.
Pschirer, Niel G., et al., “Poly(fluorenyleneethynylene)s by Alkyne Metathesis: Optical Properties and Aggregation Behavior,” Macromolecules, May 9, 2000, vol. 33, No. 11, pp. 3961-3963, American Chemical Society.
Place, Ileana,et al., “Stabilization of the Aggregation of Cyanine Dyes at the Molecular and Nanoscopic Level,” Langmuir, Jul. 28, 2000, vol. 16, No. 23, pp. 9042-9048, American Chemical Society.
Chen, Liaohai, et al., “Tuning the Properties of Conjugated Polyelectrolytes through Surfactant Complexation,” Journal of the American Chemical Society, 2000, vol. 122 No. 38, pp. 9302-9303.
Jones, Robert M., et al., “Superquenching and Its Application in J-Aggregate Cyanine Polymers,” Langmuir, Apr. 4, 2001, vol. 17, No. 9, pp. 2568-2571, American Chemical Society.
Chen, Liaohai et al., “Highly Sensitive Biological and Chemical Sensors Based on Reversible Fluorescence Quenching in a Conjugated Polymer,” Proceedings of the National Academy of Sciences of the United States of America, Oct. 26, 1999, vol. 96, No. 22, pp. 12287-12292.
Laibin, Luo, et al., “Thermodynamic Stabilization Mechanism of Block Copolymer Vessicles,” Journal of the American Chemical Society, 2001, vol. 123, No. 5, pp. 1012-1013, American Chemical Society.
Wu, Chi, et al., “Novel Nanoparticles Formed via Self-Assembly of Poly(ethylene glyco-b-sebacic anhydride) and Their Degradation in Water,” Macromolecules, Oct. 31, 2000, vol. 33, No. 24, pp. 9040-9043, American Chemical Society.
Heeger, Peter S., et al., “Making Sense of Polymer-Based Biosensors,” Proceedings of the National Academy of Sciences of the United States of America, Oct. 26, 1999, vol. 96, No. 22, pp. 12219-12221.
Li, Mei, et al., “Novel Surfactant-Free Stable Colloidal Nanoparticles Made of Randomly Carboxylated Polystyrene Ionomers,” Macromolecules, 1997, vol. 30, No. 7, pp. 2201-2203, American Chemical Society.
Zhang, Guangzhao, et al., “Formation of Novel Polymeric Nanoparticles,” Accounts of Chemical Research, Jan. 6, 2001, vol. 34, No. 3, pp. 249-256, American Chemical Society.
Sigurd, Höger, et al., “Synthesis, Aggregation, and Adsorption Phenomena of Shape-Persistent Macrocycles with Extraannular Polyalkuly Substituents,” Journal of the Amerian Chemical Society, May 22, 2001, vol. 123, No. 24, pp. 5651-5659, American Chemical Society.
Gaylord, Brent S., et al., “Water-Soluble Conjugated Oligomers: Effect of Chain Length and Aggregation on Photoluminescence-Quenching Efficiencies,” Journal of the American Chemical Society, Jun. 8, 2001, vol. 123, No. 26, pp. 6417-6418, American Chemical Society.
Harrison, Benjamin S., et al., “Amplified Fluorescence Quenching in a Poly(p-phenylene)-Based Cationic Polyelectrolyte,” Journal of the American Chemical Society, Aug. 16, 2001, vol. 122, No. 35, pp. 8561-8562, American Chemical Society.
Q. Zhou & T.M. Swager, “Methodology for Enhancing the Sensitivity of the Fluorescent Chemosensors: Energy Migration In Conjugated Polymers,” Journal of the American Chemical Society, vol. 117, No. 26, pp. 7017-7018, 1995, American Chemical Society.
J. Kim et al., “Nanoscale Fibrils and Grids: Aggregated Structures from Rigid-Rod Conjugated P
Chen Wei
Deans Robert
Hancock Lawrence F.
Cain Edward J
Nomadics, Inc.
Wolf Greenfield & Sacks P.C.
LandOfFree
Luminescent polymer particles does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Luminescent polymer particles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Luminescent polymer particles will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4047969