Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Means for analyzing gas sample
Patent
1991-02-14
1993-03-02
Warden, Robert J.
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
Means for analyzing gas sample
422 88, 422 98, 422 8207, G01N 2164
Patent
active
051907291
ABSTRACT:
An oxygen sensor is provided for determination of the partial pressure of oxygen. In one aspect, the invention consists of oxygen-quenchable luminescent lanthanide complexes for an oxygen sensor. The complexes are oxygen-quenchable even though immobilized in a solid matrix, such as a solid polymeric matrix, and preferably are terbium complexes of Schiff base or .beta.-diketone ligands. Certain preferred processes are described for improving the oxygen sensitivity of the lanthanide complexes. In another aspect, the invention consists of a combination measuring and reference analyte sensor containing both quenchable and nonquenchable luminescent materials. The materials luminesce at different wavelengths and thus may be transmitted together down a single optical fiber and later discriminated by means of filters and separtely detected. In a third aspect, the invention consists of a low-noise phosphorescent analyte sensor employing a gatable detector. By use of an analyte-quenchable material having a relatively long-lived phosphorescence, a pulsed excitation source, and selectively coupling the detector after the excitation source is off and any short-lived background luminescence has ended, a low-noise output signal consisting of the long-lived phosphorescence is selectively detected and the concentration of the analyte determined therefrom. In a preferred embodiment, all aspects of the invention are combined to produce a miniature in vivo oxygen sensor for use in the narrow blood vessels of the body.
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Brittain Harry G.
Hauenstein Bennett L.
Nestor James R.
Picerno Raysna
C. R. Bard Inc.
Mahon Timothy M.
Warden Robert J.
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