Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Patent
1991-11-04
1994-05-10
Kim, Kay K.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
436512, 436519, 436525, 436536, 436537, 436544, 436546, 436548, 436904, 436905, 435 4, 435 5, 435 6, 435 71, 422 50, 422 52, 422 8205, 422 8208, 546 2, 544225, G01N 33543, G01N 33532, C07F 1500
Patent
active
053106873
ABSTRACT:
A chemical moiety is disclosed which comprises a chemical, biochemical, or biological substance attached to one or more electrochemiluminescent organometallic compounds. In a preferred embodiment of the invention the substance is attached to one or more ruthenium-containing or osmium-containing luminescent organometallic compounds. Methods are disclosed for detecting low concentrations of the chemical moiety using chemiluminescent, electrochemiluminescent, and photoluminescent means. Compounds are disclosed which are useful for labeling substances of interest with ruthenium-containing and osmium-containing labels or other electrochemiluminescent labels. These labeled substances are useful in methods provided for detecting and quantifying analytes of interest in binding assays and competitive binding assays. The labeled substances are of particular use in homogeneous binding assays. These methods form the bases for systems designed to enable the rapid, efficient, and sensitive determination of a broad array of chemical, biochemical, and biological materials of interest.
REFERENCES:
patent: 3504052 (1970-03-01), Neuse et al.
patent: 3530049 (1970-09-01), Scherzer et al.
patent: 3793355 (1974-02-01), Wilkinson
patent: 3804869 (1974-04-01), Chabardes et al.
patent: 3966556 (1976-06-01), Rubenstein et al.
patent: 3996345 (1976-12-01), Ullman et al.
patent: 4058732 (1977-11-01), Wieder
patent: 4199559 (1980-04-01), Ullman et al.
patent: 4205952 (1980-06-01), Cais
patent: 4220722 (1980-09-01), Rowley
patent: 4238195 (1980-12-01), Boguslaski et al.
patent: 4238395 (1980-12-01), Buckler et al.
patent: 4239195 (1980-12-01), Boguslaski
patent: 4277437 (1981-07-01), Maggio
patent: 4280815 (1981-07-01), Oberhardt et al.
patent: 4293310 (1981-10-01), Weber
patent: 4318846 (1982-03-01), Khanna et al.
patent: 4352395 (1982-12-01), Buckler et al.
patent: 4352751 (1982-10-01), Wieder et al.
patent: 4363759 (1982-12-01), Boguslaski et al.
patent: 4372745 (1983-02-01), Mandle et al.
patent: 4374120 (1983-02-01), Soini et al.
patent: 4378344 (1983-03-01), Zahradnik et al.
patent: 4432907 (1984-02-01), Wieder
patent: 4459360 (1984-07-01), Marinkovich
patent: 4514508 (1985-04-01), Hirschfeld
patent: 4637988 (1987-01-01), Hinshaw et al.
patent: 4669978 (1987-10-01), Barton
patent: 4687732 (1987-08-01), Ward et al.
patent: 4687747 (1987-08-01), Lin
patent: 4699978 (1987-10-01), Barton
patent: 4707454 (1987-11-01), Hendrix
patent: 4711955 (1987-12-01), Ward et al.
patent: 4721669 (1988-01-01), Barton
patent: 4741900 (1988-05-01), Alvarez et al.
patent: 4745076 (1988-05-01), Muller et al.
patent: 4772548 (1988-09-01), Stavrianpoulos
patent: 4943523 (1990-07-01), Stavrianpoulos
patent: 4946958 (1990-10-01), Campbell et al.
The Chemistry of Ruthenium by Sedon et al pp. 414-475 Elsevier, Amsterdam 1984.
Whitehead et al (1979) Clinical Chem. 25 (9): 1531-46, Fluorescent Antibody Methods by Goldman pp. 97-117 Academic Press, New York 1968.
Practice and Theory of Enzyme Immunoassays by Tijssen pp. 279-329, Elsevier Amsterdam 1985.
Curtis et al (1977) J. Chromatography, 134: 343-350.
Weber et al (1983) Clin. Chem. 29(a):1665-1672.
CA 106:58729k Abstract to Kalyanasundaram (1986) J.C.S., Faraday Trans. 2; 82(12): 2401-15.
Van Uitert Factors Influencing the Luminescent Emission States of the Rare Earths, vol. 107, No. 10 pp. 803-806.
Sherman et al Analytical Applications of Peroxyaxalate Chemiluminescence-Analytica Chimica Acta, 97 (1978) 21-27.
Soini et al Fluoroimmunoassay: Present Status and Key Problems--Clin. Chem. 25/3, 353-361 (1979).
Rubinstein et al., J. Amer. Chem. Soc. 103:512-16 (1981).
D. Ege et al., "Electrogenerated Chemiluminescent Determination of Ru(bpy).sub.3.sup.2+ at Low Levels", Anal. Chem. 56(13) 2413-417, 1984.
Chemical Abstract 108:146746.
Ikariyama et al, "Electroluminescence-Based Homogeneous Immunoassay", Bioch. Bioph. Res, Comm., 128(2), 987-992 (1985).
C. Keszthelyl et al., "Electrogenerated Chemiluminescence: Determinatiion of Absolute Luminescence Efficiency in Electrogenerated Chemiluminescence; 9,10-Diphenylanthracene-Thianthrene and Other Systems", Anal. Chem. 47(2), 249-5 (1975).
G. Sprintschnik et al, "Preparation and Photochemical Reactivity of Surfactant Ruthenium (II) Complexes in Monolayer Assemblies and at Water Solid Interfaces", J. Amer. Chem. Soc. 99(15) 4947-4 (1977).
H. White et al, "Electrogenerated Chemiluminescence. 41. Electrogenerated Chemiluminescence and Chemiluminescence of the Ru(2,2'-bpy).sub.3.sup.2+ -S.sub.2 O.sub.8.sup.2- System in Acetonitrile-Water Solutions", J. Amer. Chem. Soc. 104(25), 6891-5 (1982).
Bard Allen J.
Whitesides George M.
IGEN, Inc.
Kim Kay K.
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