Luminescent markers

Details Luminescent markers Luminescent markers

2004-10-08

2010-06-22

Low, Christopher S. F. (Department: 1636)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S350000

Reexamination Certificate

active

07741270

ABSTRACT:
The invention relates to luminescent proteins, nucleic acids encoding same, compositions and combinations comprising the proteins, and methods using the proteins, nucleic acids, compositions and combinations. In particular, a luminescent protein is provided comprising oncomodulin in which a salt bridge has been introduced to provide greater stability. The protein may be used as a luminescent marker in, for example, luminescent items, immunoassays, and fluorescent energy transfer assays.

REFERENCES:
patent: WO98/40477 (1998-09-01), None
Chalfie et al. Green Fluorescent Protein as a Marker for Gene Expression. Science 263: 802-805, 1994.
Zheng et al. Effects of metal binding affinity on the chemical and thermal stability of site-directed mutants of rat oncomodulin. Biophysical Chem. 71: 157-172, 1998.

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