Luminescence exposure apparatus

Radiant energy – Invisible radiant energy responsive electric signalling – With or including a luminophor

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422 52, G01N 2176

Type

Patent

Status

active

Patent number

049856316

Description

ABSTRACT:
Apparatus for performing and measuring chemical reactions includes a reaction test apparatus having reaction wells wherein reactants are controllably mixed, and exposure apparatus which receives and positions the reaction test apparatus adjacent a photographic film. Each of the reaction wells includes at least two reaction chambers, arranged in a side by side fashion. All but the final reaction chamber have upwardly sloping sides, so that liquid placed in one reaction chamber can flow to the next reaction chamber when the apparatus is tilted. In a preferred embodiment, the reaction wells are supported in a plate that is structurally integral with the wells but separates the wells from each other. The test plate is retained in the exposure apparatus, and liquid is controllably flowed from one reaction chamber to the next by tilting the exposure apparatus. The apparatus of the invention is particularly suited for measuring reactions that produce luminescence of short duration, as the reactants can be conveniently mixed in darkness, while the film is being exposed.

REFERENCES:
patent: 3923462 (1975-12-01), Cavanagh
patent: 4396579 (1983-08-01), Schroeder
patent: 4510393 (1985-04-01), Sell et al.
patent: 4593728 (1986-06-01), Whitehead
patent: 4863689 (1989-09-01), Leong et al.
Dubovenko and Tovmasyan, "Chemiluminescent Determination of Microamounts of Manganese", J. Anal. Chem. USSR, vol. 25, pp. 812-814 (1970).
Isacsson and Wettermark, "Chemiluminescence in Analytical Chemistry", Analytica Chemica Acta, vol. 68, pp. 339-362 (1974).
Ulrich and Wannlund, "Bioluminescence in the Microbiology Laboratory", American Clinical Products Review, Nov. (1984).
Thorpe et al., "Photographic Monitoring of Enhanced Luminescent Immunoassays", Clinical Chemistry, pp. 806-807, vol. 30, No. 5, (1984).
Wira Technology Group, "Camera Luminometer" (2 page undated brochure).
Kricka and Thorpe, "Photographic Detection of Chemiluminescent and Bioluminescent Reactions", Methods in Enzymology, vol. 133, pp. 404-420 (1986).

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