Lubricious hydrogel surface modification

Details Lubricious hydrogel surface modification Lubricious hydrogel surface modification

1995-10-26

1998-09-08

Chen, Vivian

Stock material or miscellaneous articles

Composite

Of fluorinated addition polymer from unsaturated monomers

4284244, 428447, 428451, 428463, 4284763, 428483, 428520, 428522, 427 224, 427 225, 427 23, 427 231, 427333, 427337, 4274071, 623 1, 623 2, 623 3, 623 11, 623901, B32B 1508, B32B 2708, B32B 2730, B05D 508

Patent

active

058043187

ABSTRACT:
New and improved lubrifying coatings for reducing the coefficients of friction of surfaces on medical devices include hydrophilic copolymers derived monoethylenically-unsaturated monomers including some monomers having pendant primary amine functionality and some monomers having pendant tertiary amine functionality. The lubricious hydrogel coatings are covalently bondable to epoxy functionalized surfaces on the medical equipment to provide firmly adherent hydrogel coatings that are slippery when wet. Epoxy functionalized surfaces are provided by epoxy functional or epoxy group containing silane coupling agents. The pendant tertiary amine moieties are readily convertible at alkaline pH to quaternary ammonium cations to which anionic anti-thrombogenic agents may be bonded. Three dimensional copolymer matrices may also be provided as coatings on the surfaces by crosslinking the copolymers before or after attachment to the surface being treated.

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