Stock material or miscellaneous articles – Composite – Of polyamidoester
Patent
1997-11-26
2000-02-01
Dudash, Diana
Stock material or miscellaneous articles
Composite
Of polyamidoester
424422, 427 212, 427 23, 525453, 525454, 528 48, 528 52, B32B 2740, B05D 302, B05D 508
Patent
active
060200715
DESCRIPTION:
BRIEF SUMMARY
The present invention concerns improvements in or relating to lubricious coatings and to methods of preparation thereof and application to the surface of a substrate. More particularly, the present invention relates to a hydrophilic lubricious coating which binds to the surface of, for example, medical instruments, such as, catheters, probes or feeding tubes, which instruments, in use, are inserted into a human or animal body cavity. Such hydrophilic lubricious coating aids passage of said medical instruments into such body cavity.
In order to reduce the surface coefficient of friction of such medical instruments, over the years, a number of coatings have been developed to be applied to such medical instruments and, hence, facilitate the insertion of such medical instruments into a human or animal body cavity with minimum discomfort being experienced by the user.
In this connection, jelly-like preparations have been smeared onto the surface of medical instruments before insertion into cavities of the body. However, a major disadvantage exhibited by such jelly-like preparations was that, on removal of such medical instruments from said body cavity, such jelly-like preparations were easily dislodged from the surface of said medical instruments and, consequently, resulted in a substantial degree of discomfort being experienced by the user. Moreover, residual jelly may remain within said body cavity which can produce a focus for subsequent infection.
Realising the disadvantages of the aforementioned jelly-like preparations, numerous types of hydrophilic lubricious coatings have subsequently been developed which bind to the surface of such medical instruments and, consequently, exhibit slipperiness when wet. Moreover, such hydrophilic lubricious coatings have also substantially increased the commercial value of said medical instruments.
Such hydrophilic lubricious coatings can be applied during manufacture of such medical instruments. However, the major disadvantage exhibited by such hydrophilic lubricious coatings is that the processes developed for applying such coatings to such medical instruments comprise numerous steps, which are time consuming and as a result thereof, large scale production is less financially beneficial. Further disadvantages of such coatings are that a high proportion of soluble material used washes off in use and therefore, the effective life span of said medical instruments is substantially reduced. Furthermore, some hydrophilic lubricious coatings exhibit roughness in their dry state and consequently, such roughness may be off-putting to the user.
One such method of making such a hydrophilic lubricious coating comprises dipping the medical instrument, such as a catheter, to be coated into diphenylmethane di-isocyanate (MDI) and allowing same to dry. Such medical instrument, with a dry coating of MDI, is then dipped into a hydrophilic agent, such as polyethylene oxide, which is also allowed to dry. Subsequently, both the MDI and the hydrophilic agent are heated in order that they may react resulting in the formation of the desirable hydrophilic coating. The major disadvantage of such a process is that on adding the MDI first, an excess of the hydrophilic agent must also be added in order to ensure that the coating is not over cross-linked, since this would prevent the coating being hydrophilic. However, too much hydrophilic agent may wash off in use and consequently, be left behind in the bladder which is undesirable. Moreover, the surface of said medical instrument is rough prior to wetting and is perceived as aesthetically poor quality.
It is object of the present invention to provide a hydrophilic lubricious coating for medical instruments, such as catheters, probes or tubes, which, in use, are inserted into a human or animal body cavity, which will at least minimise some of the disadvantages exhibited by the lubricious coatings outlined above. For example, the hydrophilic lubricious coating of the present invention can be applied.
In a single step to the surface of such medical in
REFERENCES:
patent: 4100309 (1978-07-01), Micklus et al.
patent: 4729914 (1988-03-01), Kliment et al.
patent: 4835003 (1989-05-01), Becker et al.
patent: 5091205 (1992-02-01), Fan
patent: 5290585 (1994-03-01), Elton
patent: 5688855 (1997-11-01), Stoy et al.
Dudash Diana
Watson Jeremy
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