Lubricious antithrombogenic catheters, guidewires and coatings

Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...

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604266, 427 2, 427230, 4274121, A61M 532, A61M 2500, A61K 900, B05D 722

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active

051355167

ABSTRACT:
Method for rendering a preformed article lubricious and antithrombogenic and a device being the same. On the surface of the article a thin coating of a biologically compatible, lubricious, hydrophilic polymer including acid groups, is provided. On the coating, ammonium cation, and heparin are applied in the manner that heparin is bound by electrostatic attraction to the ammonium cation of the coating to permit time release of heparin. A buffer solution may be applied in a manner to act to enhance the lubriciousness of the coating.

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