Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Conjugate or complex
Reexamination Certificate
1999-04-13
2002-08-06
Criares, Theodore J. (Department: 1617)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Conjugate or complex
C514S461000, C514S465000
Reexamination Certificate
active
06428791
ABSTRACT:
FIELD OF THE INVENTION
The present invention relates to a lubricant which can be used in the mucosal areas of the human body. More particularly, there is provided a lubricating composition which can be utilized to enhance sexual activity and sexual performance in individuals.
BACKGROUND OF THE INVENTION
Topical compositions containing compounds which elevate nitrous oxide are known to enhance blood circulation which can provide males with enhanced sexual activities. Compounds such as arginine, and amino acid compounds containing arginine groups have been found to elevate nitrous oxide activity in the body.
There are additionally homeopathic compounds which can improve circulation to the body parts applied. However, some of the compounds work by way of irritation which cannot be used in the genitalia area. Compounds such as capacsin have been used but result in major irritation, even when anti-irritants are utilized.
Viagara®, which is an orally administered medicament that enhances sexual performance has numerous side effects and cannot be safely utilized over a long period of time. It is therefore advantageous to provide a topically administered composition that can produce the same results as Viagara without side effects or irritation.
It would also be advantageous to incorporate in the compositions compounds which inhibit sexually transmitted diseases (STD).
The pH of a healthy vagina is mildly acidic (pH 3.5-4.5) and this acidity is thought to be generated by the production of lactic acid by lactobacilli, which form a major component of the healthy vaginal flora. Together with other factors, this acid pH is widely recognized to prevent overgrowth of undesirable endogenous microbes (Candida, harmful anaerobes, and bacteria that may cause urinary tract infections) and encourages the continued dominance of lactobacilli which, in addition to mild acidity, provides other protective mechanisms such as production of hydrogen peroxide.
It is also known that sperm are inactivated by the mild acidity of the healthy vagina, and acid substances have been used as home made vaginal contraceptives for centuries. More recently it has been recognized that many sexually transmitted disease pathogens and most or all enveloped STD viruses (Kempf 1991, Martin 1985) including herpes simplex virus, cytomegalovirus, and human immunodeficiency virus, are also inhibited or inactivated by mild acidic pH. However, semen contains a potent alkaline buffering capacity that neutralizes the vaginal acidity for a period of many hours after intercourse. This alkaline buffering capacity enables sperm to swim from the vagina into the cervix and upper genital trace.
Unfortunately, STD pathogens in genital secretions can also exploit this period of neutral vaginal pH, since it allows time for them to reach and infect their target cells. If this semen-induced neutralization of vaginal acidity could be promptly and reliably overcome, both contraception and STD prevention could be achieved by a method that closely mimics the normal psychological state of the vagina.
In addition, the elevated pH also allows certain strains of
Staphylococcus aureus
to produce shock toxin I, whereas production of this toxin is completely inhibited at acidic pH 5.0 (Schlievert 1983). Thus, loss of protective acidity may result in staphylococcal toxic shock syndrome, candida vaginitis, bacterial vaginosis, or urinary tract infection.
SUMMARY OF THE INVENTION
The present invention relates to a lubricating composition for topical use in mucosal areas which can enhance sexual performance. The compositions of the invention comprise the combination of a compound which can either enhance blood circulation to body parts and/or increase the nitrous oxide level at the site of administration, together with a compound which can generate heat without any substantial irritation or create the feel of heat.
Preferably, there is provided homeopathic compounds which can through topical application increase blood circulation and/or increase nitrous oxide together with a heat producing compound or a compound which creates a sensation of heat in a lubrication form.
Advantageously, the heat producing compounds are phytosphinosines or sphinogomyelins.
It is, therefore, an object of the invention to provide a composition that can be used to enhance sexual activity and sexual performance.
It is another object of the invention to provide a composition which can increase blood circulation and/or nitrous oxide at the site of administration, together with heat, at the area of application.
It is yet another object of the invention to provide a homeopathic composition which can be used to increase blood circulation and/or nitrous oxide together with heat, to the areas of application.
It is a further object of the invention to provide a method for enhancing sexual activity and performance by means of a composition that can be applied to the body parts.
The compositions can be applied to external genitalia as well as internal mucosal surfaces to reduce microtrauma resulting from inadequate lubrication and will prevent transmission of viable STD pathogens.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
The compositions according to the invention may be presented in all forms normally used for topical application, in particular in the form of aqueous, aqueous-alcoholic or, oily solutions, or dispersions of the lotion or serum type, or anhydrous or lipophilic gels, or emulsions of liquid or semi-solid consistency of the milk type, obtained by dispersing a fatty phase in an aqueous phase (O/vv) or vice versa (VV/o), or of suspensions or emulsions of soft, semi-solid consistency of the cream or gel type, or alternatively of microemulsions, of microcapsules, of microparticles or of vesicular dispersions to the ionic and/or nonionic type. These compositions are prepared according to standard methods.
They may also be used in the form of aqueous, aqueous-alcoholic solutions, or in the form of creams, gels, emulsions or foams.
The amounts of the different constituents of the compositions according to the invention are those traditionally used in the pharmaceutical field.
When the composition of the invention is an emulsion, the proportion of the fatty phase can range from 5% to 80% by weight and preferably from 5% to 50% by weight, relative to the total weight of the composition. The oils, emulsifiers and coemulsifiers used in the composition in emulsion form are chosen from those traditionally used in the cosmetics. The emulsifier and the coemulsifier are present in the composition in a proportion ranging from 0.3% to 30% by weight, and preferably 0.5 to 30% or, better still, from 0.5 to 20%, by weight, relative to the total weight of the composition. The emulsion can, in addition, contain lipid vesicles.
When the compositions of the invention is an oily gel or solution, the fatty phase can represent more than 90% of the total weight of the composition.
In a known manner, the composition of the invention may also contain adjuvants which are customary in the pharmaceutical field, such as hydrophilic or lipophilic gelling agents, hydrophilic or lipophilic active agents, preservatives, antioxidants, solvents, perfumes and fillers. The amounts of these different adjuvants are those traditionally used in the pharmaceutical or dermatological field, and are, for example, from 0.01% to 10% of the total weight of the composition. Those adjuvants, depending on their nature, may be introduced into the fatty phase, into the aqueous phase and/or into lipid spherules.
As oils which can be used in the invention, mineral oils (liquid paraffin), vegetable oils (liquid fraction of sheat butter, sunflower oil), animal oils (perhydrosquatene), synthetic oils (Purcellin oil), silicone oils (cyclomethicone) and fluorinated oils (perfluoro polyethers) may be mentioned.
Fatty alcohols, fatty acids (stearic acid) and waxes (paraffin, carnauba, beeswax) may also be used as fatty substances.
As emulsifiers which can be used in the invention, glycerol stearate, polysorbate 60 and the PEG-6/PEG-32/glycol s
Lezdey Jarett
Lezdey John
Alphamed Pharmace Vticals, Corp
Criares Theodore J.
Lezdey John
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