Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Chemical modification or the reaction product thereof – e.g.,...
Patent
1992-04-03
1994-05-10
Wityshyn, Michael G.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Chemical modification or the reaction product thereof, e.g.,...
530402, 530395, 530350, 530404, 436504, 436545, 436804, C07K 306, C07K 1514, C07K 700
Patent
active
053108841
ABSTRACT:
The LTD.sub.4 receptor has been defined by radioligand binding studies as a member of the family of G-protein coupled receptors. A photoactivable azido derivative of LTD.sub.4 ([.sup.125 I]Azido-LTD.sub.4) has been synthesized for use as a photoaffinity probe. Photoactivation of ([.sup.125 I]Azido-LTD.sub.4 under equilibrium binding conditions revealed the selective radiolabeling of a 45 kDa protein in guinea-pig lung membranes, as visualized by SDS-PAGE and autoradiography.
REFERENCES:
Mong et al., Mol. Pharmacol 29: 235-243 (1986).
Mong and Sarau, Mol. Pharmacol 37: 60-64 (1990).
Watanabe, J. Biol. Chem. 265: 21237-21241 (1990).
Metters Kathleen M.
Zamboni Robert
Daniel Mark R.
DiPrima Joseph F.
Merck Frosst Canada Inc.
Sayala C.
Wityshyn Michael G.
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